Increased granulocyte colony-stimulating factor responsiveness but normal resting granulopoiesis in mice carrying a targeted granulocyte colony-stimulating factor receptor mutation derived from a patient with severe congenital neutropenia.

McLemore, M L; Poursine-Laurent, J; Link, D C

McLemore, M L; Poursine-Laurent, J; Link, D C.

Affiliation

McLemore ML; Division of Bone Marrow Transplantation and Stem Cell Biology, Department of Medicine, and Department of Pathology, Washington University Medical School, St. Louis, Missouri 63110, USA.

J Clin Invest ; 102(3): 483-92, 1998 Aug 01.

Article in En | MEDLINE | ID: mdl-9691084

Subject(s)

Granulocyte Colony-Stimulating Factor/pharmacology; Hematopoiesis/drug effects; Neutropenia/genetics; Receptors, Granulocyte Colony-Stimulating Factor/deficiency; Acute Disease; Animals; Apoptosis/drug effects; Bone Marrow/pathology; Cell Division/drug effects; Disease Susceptibility; Female; Genotype; Humans; Leukemia, Myeloid/etiology; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Myelodysplastic Syndromes/etiology; Neutropenia/congenital; Neutropenia/pathology; Neutrophils/pathology; Receptors, Granulocyte Colony-Stimulating Factor/drug effects; Receptors, Granulocyte Colony-Stimulating Factor/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Granulocyte Colony-Stimulating Factor / Receptors, Granulocyte Colony-Stimulating Factor / Hematopoiesis / Neutropenia Type of study: Etiology_studies Limits: Animals / Female / Humans / Male Language: En Journal: J Clin Invest Year: 1998 Document type: Article Affiliation country: United States Country of publication: United States

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