Species- and sex-related differences in metabolism of trichloroethylene to yield chloral and trichloroethanol in mouse, rat, and human liver microsomes.

Elfarra, A A; Krause, R J; Last, A R; Lash, L H; Parker, J C

Elfarra, A A; Krause, R J; Last, A R; Lash, L H; Parker, J C.

Affiliation

Elfarra AA; Department of Comparative Biosciences, University of Wisconsin School of Veterinary Medicine, Madison, WI 53706, USA.

Drug Metab Dispos ; 26(8): 779-85, 1998 Aug.

Article in En | MEDLINE | ID: mdl-9698293

Subject(s)

Chloral Hydrate/analogs & derivatives; Ethylene Chlorohydrin/analogs & derivatives; Microsomes, Liver/metabolism; Solvents/metabolism; Trichloroethylene/metabolism; Acetates/metabolism; Animals; Chloral Hydrate/metabolism; Dichloroacetic Acid/metabolism; Ethylene Chlorohydrin/metabolism; Female; Glyoxylates/metabolism; Humans; Kinetics; Male; Mice; NADP/metabolism; NADP/pharmacology; Oxalates/metabolism; Oxalic Acid; Rats; Rats, Inbred F344; Sex Factors; Species Specificity

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Collection: 01-internacional Database: MEDLINE Main subject: Solvents / Trichloroethylene / Microsomes, Liver / Chloral Hydrate / Ethylene Chlorohydrin Limits: Animals / Female / Humans / Male Language: En Journal: Drug Metab Dispos Journal subject: FARMACOLOGIA Year: 1998 Document type: Article Affiliation country: United States

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