Regenerating functional myocardium: improved performance after skeletal myoblast transplantation.
Nat Med
; 4(8): 929-33, 1998 Aug.
Article
in En
| MEDLINE
| ID: mdl-9701245
ABSTRACT
The adult heart lacks reserve cardiocytes and cannot regenerate. Therefore, a large acute myocardial infarction often develops into congestive heart failure. To attempt to prevent this progression, we transplanted skeletal myoblasts into cryoinfarcted myocardium of the same rabbits (autologous transfer), monitored cardiac function in vivo for two to six weeks and examined serial sections of the hearts by light and electron microscopy. Islands of different sizes comprising elongated, striated cells that retained characteristics of both skeletal and cardiac cells were found in the cryoinfarct. In rabbits in which myoblasts were incorporated, myocardial performance was improved. The ability to regenerate functioning muscle after autologous myoblast transplantation could have a important effect on patients after acute myocardial infarction.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Regeneration
/
Cell Transplantation
/
Muscle, Skeletal
/
Heart
/
Myocardial Infarction
/
Myocardium
Limits:
Animals
Language:
En
Journal:
Nat Med
Journal subject:
BIOLOGIA MOLECULAR
/
MEDICINA
Year:
1998
Document type:
Article
Affiliation country:
United States