A minimal glycine-alanine repeat prevents the interaction of ubiquitinated I kappaB alpha with the proteasome: a new mechanism for selective inhibition of proteolysis.

Sharipo, A; Imreh, M; Leonchiks, A; Imreh, S; Masucci, M G

Sharipo, A; Imreh, M; Leonchiks, A; Imreh, S; Masucci, M G.

Affiliation

Sharipo A; Microbiology and Tumor Biology Center, Karolinska Institute, Stockholm, Sweden.

Nat Med ; 4(8): 939-44, 1998 Aug.

Article in En | MEDLINE | ID: mdl-9701247

Subject(s)

Cysteine Endopeptidases/metabolism; DNA-Binding Proteins/chemistry; DNA-Binding Proteins/metabolism; Dipeptides; I-kappa B Proteins; Multienzyme Complexes/metabolism; Ubiquitins/metabolism; Amino Acid Sequence; Apoptosis; Binding Sites; DNA-Binding Proteins/genetics; Genes, Dominant; Glycosylation; HeLa Cells; Humans; Kinetics; Molecular Sequence Data; NF-KappaB Inhibitor alpha; NF-kappa B/antagonists & inhibitors; Proteasome Endopeptidase Complex; Recombinant Proteins/biosynthesis; Recombinant Proteins/chemistry; Recombinant Proteins/metabolism; Signal Transduction; Transfection

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Collection: 01-internacional Database: MEDLINE Main subject: Cysteine Endopeptidases / Ubiquitins / I-kappa B Proteins / Dipeptides / DNA-Binding Proteins / Multienzyme Complexes Type of study: Prognostic_studies Limits: Humans Language: En Journal: Nat Med Journal subject: BIOLOGIA MOLECULAR / MEDICINA Year: 1998 Document type: Article Affiliation country: Sweden Country of publication: United States

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