Computer-assisted rational design of immunosuppressive compounds.

Grassy, G; Calas, B; Yasri, A; Lahana, R; Woo, J; Iyer, S; Kaczorek, M; Floc'h, R; Buelow, R

Grassy, G; Calas, B; Yasri, A; Lahana, R; Woo, J; Iyer, S; Kaczorek, M; Floc'h, R; Buelow, R.

Affiliation

Grassy G; Centre de Biochimie Structurale, UMR CNRS 9955, INSERM U414, Faculté de Pharmacie, Montpellier, France.

Nat Biotechnol ; 16(8): 748-52, 1998 Aug.

Article in En | MEDLINE | ID: mdl-9702773

Subject(s)

Computer-Aided Design; Drug Design; Graft Survival/drug effects; Immunosuppressive Agents; Peptides; Animals; Computer Simulation; Consensus Sequence; Drug Evaluation, Preclinical; Heart Transplantation; Histocompatibility Antigens Class I; Humans; Immunosuppressive Agents/chemistry; Immunosuppressive Agents/pharmacology; Immunosuppressive Agents/therapeutic use; Ligands; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Peptide Library; Peptides/chemistry; Peptides/pharmacology; Peptides/therapeutic use; Protein Conformation; T-Lymphocytes, Cytotoxic/immunology; Transplantation, Homologous/immunology

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Collection: 01-internacional Database: MEDLINE Main subject: Peptides / Drug Design / Computer-Aided Design / Graft Survival / Immunosuppressive Agents Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Nat Biotechnol Journal subject: BIOTECNOLOGIA Year: 1998 Document type: Article Affiliation country: France

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