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The alpha-synuclein Ala53Thr mutation is not a common cause of familial Parkinson's disease: a study of 230 European cases. European Consortium on Genetic Susceptibility in Parkinson's Disease.
Vaughan, J; Durr, A; Tassin, J; Bereznai, B; Gasser, T; Bonifati, V; De Michele, G; Fabrizio, E; Volpe, G; Bandmann, O; Johnson, W G; Golbe, L I; Breteler, M; Meco, G; Agid, Y; Brice, A; Marsden, C D; Wood, N W.
Affiliation
  • Vaughan J; University Department of Clinical Neurology, Institute of Neurology, London, UK.
Ann Neurol ; 44(2): 270-3, 1998 Aug.
Article in En | MEDLINE | ID: mdl-9708553
ABSTRACT
We report the results of a screen of 230 European familial index cases of Parkinson's disease for the recently described Ala53Thr mutation in the alpha-synuclein gene in an autosomal dominant Parkinson's disease kindred. No mutations were found from this broad white population, and we therefore conclude that although of great interest, this mutation is a very rare cause of familial Parkinson's disease.
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Collection: 01-internacional Database: MEDLINE Main subject: Parkinson Disease / Phosphoproteins / White People / Nerve Tissue Proteins Limits: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: En Journal: Ann Neurol Year: 1998 Document type: Article Affiliation country: United kingdom
Search on Google
Add to My VHL
Print
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PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Parkinson Disease / Phosphoproteins / White People / Nerve Tissue Proteins Limits: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: En Journal: Ann Neurol Year: 1998 Document type: Article Affiliation country: United kingdom