Collagenase-1 and collagen in epidermal repair.
Arch Dermatol Res
; 290 Suppl: S37-46, 1998 Jul.
Article
in En
| MEDLINE
| ID: mdl-9710382
ABSTRACT
An invariable feature of wounded skin, whether a normally healing or chronic lesion, is the expression of collagenase-1 by migrating basal keratinocytes. Collagenase-1 is a member of the matrix metalloproteinase family of enzymes and is the principal human enzyme which cleaves native fibrillar collagen. Following injury, basal keratinocytes move from the basement membrane and interact with new connective tissue proteins in the dermis and wound bed. Contact with native type I collagen, the most abundant protein in the dermis, induces expression of collagenase-1. This metalloproteinase cleaves collagen, thereby altering its structure and, hence, the affinity to which cells bind it. Thus, collagenase-1 serves a beneficial role in wound healing by facilitating the movement of keratinocytes over the collagen-rich dermis during reepithelialization.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Skin
/
Wound Healing
/
Wounds and Injuries
/
Collagen
/
Collagenases
Limits:
Animals
/
Humans
Language:
En
Journal:
Arch Dermatol Res
Year:
1998
Document type:
Article
Affiliation country:
United States