Endotoxin and cytokines increase hepatic sphingolipid biosynthesis and produce lipoproteins enriched in ceramides and sphingomyelin.

Memon, R A; Holleran, W M; Moser, A H; Seki, T; Uchida, Y; Fuller, J; Shigenaga, J K; Grunfeld, C; Feingold, K R

Memon, R A; Holleran, W M; Moser, A H; Seki, T; Uchida, Y; Fuller, J; Shigenaga, J K; Grunfeld, C; Feingold, K R.

Affiliation

Memon RA; Department of Medicine, University of California, San Francisco, USA.

Arterioscler Thromb Vasc Biol ; 18(8): 1257-65, 1998 Aug.

Article in En | MEDLINE | ID: mdl-9714132

Subject(s)

Ceramides/biosynthesis; Cytokines/pharmacology; Endotoxins/pharmacology; Escherichia coli; Lipoproteins/drug effects; Liver/drug effects; Sphingomyelins/biosynthesis; Acyltransferases/analysis; Acyltransferases/drug effects; Acyltransferases/metabolism; Animals; Ceramides/analysis; Cricetinae; Humans; Lipoproteins/analysis; Lipoproteins/biosynthesis; Liver/chemistry; Liver/enzymology; Male; Mesocricetus; RNA, Messenger/analysis; RNA, Messenger/biosynthesis; RNA, Messenger/drug effects; Serine C-Palmitoyltransferase; Sphingomyelins/analysis; Stimulation, Chemical; Tumor Cells, Cultured

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Collection: 01-internacional Database: MEDLINE Main subject: Sphingomyelins / Ceramides / Cytokines / Endotoxins / Escherichia coli / Lipoproteins / Liver Limits: Animals / Humans / Male Language: En Journal: Arterioscler Thromb Vasc Biol Journal subject: ANGIOLOGIA Year: 1998 Document type: Article Affiliation country: United States

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