Novel nonsteroidal inhibitor of cytochrome P450(17alpha) (17alpha-hydroxylase/C17-20 lyase), YM116, decreased prostatic weights by reducing serum concentrations of testosterone and adrenal androgens in rats.

Ideyama, Y; Kudoh, M; Tanimoto, K; Susaki, Y; Nanya, T; Nakahara, T; Ishikawa, H; Yoden, T; Okada, M; Fujikura, T; Akaza, H; Shikama, H

Ideyama, Y; Kudoh, M; Tanimoto, K; Susaki, Y; Nanya, T; Nakahara, T; Ishikawa, H; Yoden, T; Okada, M; Fujikura, T; Akaza, H; Shikama, H.

Affiliation

Ideyama Y; Metabolic Diseases Research, Pharmacology Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co., Ltd., Tsukuba, Ibaraki, Japan.

Prostate ; 37(1): 10-8, 1998 Sep 15.

Article in En | MEDLINE | ID: mdl-9721064

Subject(s)

Androgens/blood; Carbazoles/pharmacology; Enzyme Inhibitors/pharmacology; Imidazoles/pharmacology; Prostate/anatomy & histology; Steroid 17-alpha-Hydroxylase/antagonists & inhibitors; Testosterone/blood; Abiraterone Acetate; Adrenal Glands/physiology; Adrenocorticotropic Hormone/pharmacology; Androgens/biosynthesis; Androstadienes/pharmacology; Animals; Gonadotropin-Releasing Hormone/pharmacology; Guinea Pigs; Ketoconazole/pharmacology; Male; Orchiectomy; Organ Size; Rats; Seminal Vesicles/anatomy & histology; Steroid 17-alpha-Hydroxylase/metabolism; Testosterone/biosynthesis

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Collection: 01-internacional Database: MEDLINE Main subject: Prostate / Testosterone / Carbazoles / Steroid 17-alpha-Hydroxylase / Enzyme Inhibitors / Imidazoles / Androgens Limits: Animals Language: En Journal: Prostate Year: 1998 Document type: Article Affiliation country: Japan Country of publication: United States

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