Oral bioavailability and disposition characteristics of irbesartan, an angiotensin antagonist, in healthy volunteers.
J Clin Pharmacol
; 38(8): 702-7, 1998 Aug.
Article
in En
| MEDLINE
| ID: mdl-9725545
ABSTRACT
Absolute oral bioavailability and disposition characteristics of irbesartan, an angiotensin II receptor antagonist, were investigated in 18 healthy young male volunteers. Subjects received [14C] irbesartan as a 30-minute intravenous infusion (50 mg), [14C] irbesartan orally as a solution (50 mg or 150 mg), or irbesartan capsule (50 mg). Irbesartan was rapidly and almost completely absorbed after oral administration, and exhibited a mean absolute oral bioavailability of 60% to 80%. Mean total body clearance was approximately 157 mL/min, and renal clearance was 3.0 mL/min. Volume of distribution at steady state was 53 L to 93 L, and terminal elimination half-life was approximately 13 to 16 hours. Hepatic extraction ratio was low (0.2). There were no major circulating metabolites, and approximately 80% of total plasma radioactivity was attributable to unchanged irbesartan. Regardless of route of administration, approximately 20% of dose was recovered in urine and the remainder in feces.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Tetrazoles
/
Biphenyl Compounds
/
Angiotensin II
/
Angiotensin Receptor Antagonists
Type of study:
Clinical_trials
/
Prognostic_studies
Limits:
Adult
/
Humans
/
Male
Language:
En
Journal:
J Clin Pharmacol
Year:
1998
Document type:
Article
Affiliation country:
United States