Recombinant IFN-gamma treatment of a patient with hyperimmunoglobulin E syndrome triggered autoimmune thrombocytopenia.
J Interferon Cytokine Res
; 18(8): 561-3, 1998 Aug.
Article
in En
| MEDLINE
| ID: mdl-9726436
ABSTRACT
We report a pediatric patient with hyperimmunoglobulin E syndrome (HIES) treated with recombinant IFN-gamma (rIFN-gamma) for 2 1/4 years who developed autoimmune thrombocytopenia and was positive for serum antiplatelet antibody and antinuclear antibody (ANA). She was then treated with i.v. methylprednisolone pulse therapy followed by oral immunosuppressive drugs. With this therapy, her platelet count increased and was maintained within the normal range for more than a year. We retrospectively examined her sera stored at -40 degrees C for ANA and found that the ANA level was increased from 140 to 1640 with the rIFN-y therapy. Therefore, we believe that, in this case, rIFN-y treatment may have played a crucial role in triggering autoimmune thrombocytopenia. Furthermore, this case demonstrates that caution must be observed in administering rIFN-gamma to genetically predisposed patients.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Autoimmune Diseases
/
Thrombocytopenia
/
Blood Platelets
/
Interferon-gamma
/
Job Syndrome
Limits:
Child
/
Female
/
Humans
Language:
En
Journal:
J Interferon Cytokine Res
Journal subject:
ALERGIA E IMUNOLOGIA
Year:
1998
Document type:
Article
Affiliation country:
Japan
Publication country:
EEUU
/
ESTADOS UNIDOS
/
ESTADOS UNIDOS DA AMERICA
/
EUA
/
UNITED STATES
/
UNITED STATES OF AMERICA
/
US
/
USA