Functional aspects of the X-ray structure of mitochondrial creatine kinase: a molecular physiology approach.
Mol Cell Biochem
; 184(1-2): 125-40, 1998 Jul.
Article
in En
| MEDLINE
| ID: mdl-9746317
ABSTRACT
Mitochondrial creatine kinase (Mi-CK) is a central enzyme in energy metabolism of tissues with high and fluctuating energy requirements. In this review, recent progress in the functional and structural characterization of Mi-CK is summarized with special emphasis on the solved X-ray structure of chicken Mib-CK octamer (Fritz-Wolf et al., Nature 381, 341-345, 1996). The new results are discussed in a historical context and related to the characteristics of CK isoforms as known from a large number of biophysical and biochemical studies. Finally, two hypothetical functional aspects of the Mi-CK structure are proposed (i) putative membrane binding motifs at the top and bottom faces of the octamer and (ii) a possible functional role of the central 20 A channel.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Creatine Kinase
/
Mitochondria
Type of study:
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
Mol Cell Biochem
Year:
1998
Document type:
Article