A unique autosomal dominant disorder with indifference to pain: clinicopathologic correlation of indifference to pain and thalamic gliosis.
Eur Neurol
; 40(3): 141-5, 1998 Oct.
Article
in En
| MEDLINE
| ID: mdl-9748671
ABSTRACT
We present updated information on a previously reported kindred with an autosomal dominant disorder variably expressed as indifference to pain, dementia, and ataxia. Additional clinical and radiological information is presented, as are autopsy results form the index case. In addition to evidence of Alzheimer's disease, the autopsy revealed bilateral thalamic gliosis, which may be a neuroanatomic substrate for the indifference to pain seen in this patient. To our knowledge, this is the first reported association of thalamic gliosis and indifference to pain.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Thalamus
/
Pain Insensitivity, Congenital
/
Gliosis
Type of study:
Diagnostic_studies
Limits:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Eur Neurol
Year:
1998
Document type:
Article
Affiliation country:
United States