F(ab')2 molecules made from Escherichia coli produced Fab' with hinge sequences conferring increased serum survival in an animal model.

Humphreys, D P; Vetterlein, O M; Chapman, A P; King, D J; Antoniw, P; Suitters, A J; Reeks, D G; Parton, T A; King, L M; Smith, B J; Lang, V; Stephens, P E

Humphreys, D P; Vetterlein, O M; Chapman, A P; King, D J; Antoniw, P; Suitters, A J; Reeks, D G; Parton, T A; King, L M; Smith, B J; Lang, V; Stephens, P E.

Affiliation

Humphreys DP; Celltech Therapeutics, Slough, Berkshire, UK. dhumphre@celltech.co.uk

J Immunol Methods ; 217(1-2): 1-10, 1998 Aug 01.

Article in En | MEDLINE | ID: mdl-9776570

Subject(s)

Immunoglobulin Fab Fragments/immunology; Immunoglobulin G/immunology; Amino Acid Sequence; Animals; Antibody Affinity; Cystine/analysis; Dimerization; Escherichia coli/metabolism; Genes, Immunoglobulin; Humans; Immunoglobulin Fab Fragments/blood; Immunoglobulin Fab Fragments/genetics; Immunoglobulin G/blood; Immunoglobulin G/genetics; Male; Mice; Molecular Sequence Data; Oxidation-Reduction; Protein Conformation; Rats; Rats, Sprague-Dawley; Recombinant Fusion Proteins/blood; Recombinant Fusion Proteins/immunology

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Collection: 01-internacional Database: MEDLINE Main subject: Immunoglobulin G / Immunoglobulin Fab Fragments Type of study: Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: J Immunol Methods Year: 1998 Document type: Article Affiliation country: United kingdom Country of publication: Netherlands

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