Chymase gene locus is not associated with myocardial infarction and is not linked to heart size or blood pressure.

Pfeufer, A; Busjahn, A; Vergopoulos, A; Knoblauch, H; Urata, H; Osterziel, K J; Menz, M; Wienker, T F; Faulhaber, H D; Steinmetz, A; Schuster, H; Dietz, R; Luft, F C

Pfeufer, A; Busjahn, A; Vergopoulos, A; Knoblauch, H; Urata, H; Osterziel, K J; Menz, M; Wienker, T F; Faulhaber, H D; Steinmetz, A; Schuster, H; Dietz, R; Luft, F C.

Affiliation

Pfeufer A; Franz Volhard Clinic and Max Delbrück Center for Molecular Medicine, Virchow Klinikum, Humboldt University of Berlin, Germany.

Am J Cardiol ; 82(8): 979-81, 1998 Oct 15.

Article in En | MEDLINE | ID: mdl-9794357

ABSTRACT

ABSTRACT

The chymase gene is said to be important for the generation of angiotensin II in the heart and therefore is a candidate gene for heart disease. However, we were unable to find an association between allelic variants of the chymase gene and acute myocardial infarction or linkage between the chymase gene locus and heart size.

Subject(s)

Blood Pressure/genetics; Cardiomegaly/genetics; Myocardial Infarction/genetics; Serine Endopeptidases/genetics; Twins/genetics; Adult; Base Sequence; Chymases; Female; Genetic Linkage; Genotype; Humans; Male; Microsatellite Repeats; Molecular Sequence Data; Polymorphism, Genetic; Reference Values

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Collection: 01-internacional Database: MEDLINE Main subject: Twins / Blood Pressure / Serine Endopeptidases / Cardiomegaly / Myocardial Infarction Type of study: Risk_factors_studies Limits: Adult / Female / Humans / Male Language: En Journal: Am J Cardiol Year: 1998 Document type: Article Affiliation country: Germany

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