Randomised controlled trial of brief neonatal exposure to cows' milk on the development of atopy.
Arch Dis Child
; 79(2): 126-30, 1998 Aug.
Article
in En
| MEDLINE
| ID: mdl-9797592
ABSTRACT
OBJECTIVE:
To determine the effect of brief early exposure to cows' milk on atopy in the first 2 years of life.DESIGN:
Double blind, placebo controlled, randomised feeding intervention trial (Bokaal study).SETTING:
Dutch midwifery practices.PARTICIPANTS:
1533 breast fed neonates. INTERVENTION Exposure to cows' milk protein (n = 758) or a protein free placebo (n = 775) during the first 3 days of life. MAIN OUTCOMEMEASURES:
Clinical atopic disease and any positive radioallergosorbent (RAST) tests at 1 year of age.RESULTS:
Atopic disease in the first year was found in 10.0% (cows' milk) v 9.3% (placebo) of the children, with a relative risk of 1.07; in the second year, atopic disease was found in 9.6% v 10.2%, respectively, with a relative risk of 0.94. Per protocol analysis showed similar results. Any RAST positive test was found in 9.4% (cows' milk) v 7.9% (placebo) of children, with a relative risk of 1.19. Stratified analysis for high family risk of allergy showed a doubled incidence of atopic disease but no effect from the intervention.CONCLUSION:
Early and brief exposure to cows' milk in breast fed children does not increase the risk of atopic disease in the first 2 years.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Milk
/
Hypersensitivity, Immediate
/
Infant Nutritional Physiological Phenomena
Type of study:
Clinical_trials
/
Etiology_studies
/
Guideline
/
Observational_studies
/
Prognostic_studies
Limits:
Animals
/
Female
/
Humans
/
Male
/
Newborn
Language:
En
Journal:
Arch Dis Child
Year:
1998
Document type:
Article
Affiliation country:
Netherlands