[Ofuji's papulo-erythroderma: treatment with cyclosporin A]. / Papulo-érythrodermie d'Ofuji: traitement par ciclosporine-A.
Ann Dermatol Venereol
; 125(9): 589-92, 1998 Sep.
Article
in Fr
| MEDLINE
| ID: mdl-9805546
ABSTRACT
BACKGROUND:
Papuloerythroderma of Ofuji is an uncommon condition characterized by diffuse pruriginous eruptions of infiltrating papulae. The large folds are not involved. The eruptions are associated with lymphopenia and eosinophilia. Very few cases have been reported in the literature and because of their heterogeneous nature, there is some debate as to whether this is a single clinical entity or a particular presentation of erythrodermia; Immunomodulation is recommended. CASE REPORT A 73 year-old man of asian origin living in France presented chronic pruriginous erythrodermia with flat purplish-brown confluent papulae which did not involve the large folds. Eosophilia and lymphopenia were present. The biopsy specimen evidenced dermal infiltration with CD4+CD45+RO+ T cells, eosinophils and DC1a+ dendritic cells. Further explorations did not reveal any sign favoring lymphoma, carcinoma or underlying infection. Dermocorticoids, PUVA-therapy and interferon-alpha were ineffective. Considerable clinical improvement was obtained with cyclosporine A.DISCUSSION:
We used ciclosporine A in our patient after repeated failure of other therapies reported to be effective in this dermatosis. Despite the favorable outcome, this therapeutic approach should be used with prudence.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Skin Diseases, Vesiculobullous
/
Cyclosporine
/
Dermatitis, Exfoliative
/
Dermatologic Agents
/
Immunosuppressive Agents
Limits:
Aged
/
Humans
/
Male
Language:
Fr
Journal:
Ann Dermatol Venereol
Year:
1998
Document type:
Article