SH3GL3 associates with the Huntingtin exon 1 protein and promotes the formation of polygln-containing protein aggregates.

Sittler, A; Wälter, S; Wedemeyer, N; Hasenbank, R; Scherzinger, E; Eickhoff, H; Bates, G P; Lehrach, H; Wanker, E E

Sittler, A; Wälter, S; Wedemeyer, N; Hasenbank, R; Scherzinger, E; Eickhoff, H; Bates, G P; Lehrach, H; Wanker, E E.

Affiliation

Sittler A; Max-Planck-Institut für Molekulare Genetik, Berlin, Germany.

Mol Cell ; 2(4): 427-36, 1998 Oct.

Article in En | MEDLINE | ID: mdl-9809064

Subject(s)

Carrier Proteins/genetics; Carrier Proteins/metabolism; Glutamine/genetics; Huntington Disease/genetics; Nerve Tissue Proteins/genetics; Nuclear Proteins/genetics; src Homology Domains/genetics; Adaptor Proteins, Signal Transducing; Animals; Brain Chemistry; COS Cells; Carrier Proteins/isolation & purification; Exons/genetics; Gene Expression; Glutamine/metabolism; Humans; Huntingtin Protein; Nerve Tissue Proteins/isolation & purification; Nerve Tissue Proteins/metabolism; Nuclear Proteins/isolation & purification; Nuclear Proteins/metabolism; Peptide Fragments/genetics; Peptide Fragments/metabolism; Precipitin Tests; Proline; RNA, Messenger/analysis; Rabbits; Repetitive Sequences, Nucleic Acid; Subcellular Fractions/chemistry; Yeasts/genetics

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Collection: 01-internacional Database: MEDLINE Main subject: Nuclear Proteins / Carrier Proteins / Huntington Disease / Src Homology Domains / Glutamine / Nerve Tissue Proteins Type of study: Risk_factors_studies Limits: Animals / Humans Language: En Journal: Mol Cell Journal subject: BIOLOGIA MOLECULAR Year: 1998 Document type: Article Affiliation country: Germany Country of publication: United States

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