Beta-chemokines MCP-1 and RANTES are selectively increased in cerebrospinal fluid of patients with human immunodeficiency virus-associated dementia.
Ann Neurol
; 44(5): 831-5, 1998 Nov.
Article
in En
| MEDLINE
| ID: mdl-9818943
ABSTRACT
Human immunodeficiency virus-associated dementia (HAD) is associated with increased numbers of activated central nervous system (CNS) macrophages. Chemokines, which regulate infiltration of macrophages, were measured in the cerebrospinal fluid (CSF) of human immunodeficiency virus (HIV)-negative and HIV-positive individuals with and without neurological disease. Monocyte chemotactic protein (MCP)-1 and RANTES (but not MCP-3), macrophage inflammatory protein (MIP)-1alpha, MIP-1beta, or interleukin-8 (IL-8) was higher in HAD. MCP-1 correlated with CSF viral load and severity of dementia, and it increased over time in patients who developed dementia.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cytokines
/
AIDS Dementia Complex
/
HIV Seropositivity
/
Chemokine CCL5
/
Chemokine CCL2
Type of study:
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
Limits:
Humans
Language:
En
Journal:
Ann Neurol
Year:
1998
Document type:
Article
Affiliation country:
United States