Preparation and antimicrobial assessment of 2-thioether-linked quinolonyl-carbapenems.
J Antibiot (Tokyo)
; 51(9): 857-71, 1998 Sep.
Article
in En
| MEDLINE
| ID: mdl-9820237
ABSTRACT
This reports the synthesis and in vitro antimicrobial properties of a series of 2-thioether-linked quinolonyl-carbapenems. Although the title compounds exhibited broad spectrum activity, the MICs were generally higher than those observed for selected benchmark carbapenems, quinolonyl-penems, and quinolones. Enzyme assays suggested that the title compounds are potent inhibitors of penicillin binding proteins and inefficient inhibitors of bacterial DNA-gyrase. Uptake studies indicated that the new compounds are not substrates for the norA encoded quinolone efflux pump.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Carbapenems
/
Quinolones
/
Gram-Negative Bacteria
/
Gram-Positive Bacteria
Language:
En
Journal:
J Antibiot (Tokyo)
Year:
1998
Document type:
Article
Affiliation country:
United States