Heterotrimeric G proteins physically associated with the lipopolysaccharide receptor CD14 modulate both in vivo and in vitro responses to lipopolysaccharide.

Solomon, K R; Kurt-Jones, E A; Saladino, R A; Stack, A M; Dunn, I F; Ferretti, M; Golenbock, D; Fleisher, G R; Finberg, R W

Solomon, K R; Kurt-Jones, E A; Saladino, R A; Stack, A M; Dunn, I F; Ferretti, M; Golenbock, D; Fleisher, G R; Finberg, R W.

Affiliation

Solomon KR; Infectious Disease Unit, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA.

J Clin Invest ; 102(11): 2019-27, 1998 Dec 01.

Article in En | MEDLINE | ID: mdl-9835628

Subject(s)

GTP-Binding Proteins/physiology; Lipopolysaccharide Receptors/physiology; Lipopolysaccharides/pharmacology; Shock, Septic/physiopathology; Signal Transduction/drug effects; Animals; Cell Line; GTP-Binding Proteins/isolation & purification; Humans; Intercellular Signaling Peptides and Proteins; Leukocytes, Mononuclear/drug effects; Leukocytes, Mononuclear/metabolism; Lipopolysaccharide Receptors/drug effects; Lipopolysaccharide Receptors/isolation & purification; Lipopolysaccharides/toxicity; Monocytes/drug effects; Monocytes/metabolism; Peptides; Rats; Recombinant Fusion Proteins/physiology; Shock, Septic/etiology; Shock, Septic/prevention & control; Signal Transduction/physiology; Transfection; Virulence Factors, Bordetella/pharmacology; Wasp Venoms/pharmacology; Wasp Venoms/therapeutic use

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Shock, Septic / Signal Transduction / Lipopolysaccharides / Lipopolysaccharide Receptors / GTP-Binding Proteins Type of study: Etiology_studies / Risk_factors_studies Limits: Animals / Humans Language: En Journal: J Clin Invest Year: 1998 Document type: Article Affiliation country: United States Country of publication: United States

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