Nitrogen-carbon-linked (azolylphenyl)oxazolidinones with potent antibacterial activity against the fastidious gram-negative organisms Haemophilus influenzae and Moraxella catarrhalis.

Genin, M J; Hutchinson, D K; Allwine, D A; Hester, J B; Emmert, D E; Garmon, S A; Ford, C W; Zurenko, G E; Hamel, J C; Schaadt, R D; Stapert, D; Yagi, B H; Friis, J M; Shobe, E M; Adams, W J

Genin, M J; Hutchinson, D K; Allwine, D A; Hester, J B; Emmert, D E; Garmon, S A; Ford, C W; Zurenko, G E; Hamel, J C; Schaadt, R D; Stapert, D; Yagi, B H; Friis, J M; Shobe, E M; Adams, W J.

Affiliation

Genin MJ; Pharmacia & Upjohn, Inc., Kalamazoo, Michigan 49001, USA.

J Med Chem ; 41(26): 5144-7, 1998 Dec 17.

Article in En | MEDLINE | ID: mdl-9857083

Subject(s)

Anti-Bacterial Agents/chemical synthesis; Haemophilus influenzae/drug effects; Moraxella catarrhalis/drug effects; Oxazoles/chemical synthesis; Pyrazoles/chemical synthesis; Pyrroles/chemical synthesis; Administration, Oral; Animals; Anti-Bacterial Agents/chemistry; Anti-Bacterial Agents/pharmacokinetics; Anti-Bacterial Agents/pharmacology; Colony Count, Microbial; Inhibitory Concentration 50; Injections, Intravenous; Male; Mice; Oxazoles/chemistry; Oxazoles/pharmacokinetics; Oxazoles/pharmacology; Pyrazoles/chemistry; Pyrazoles/pharmacokinetics; Pyrazoles/pharmacology; Pyrroles/chemistry; Pyrroles/pharmacokinetics; Pyrroles/pharmacology; Rats; Rats, Sprague-Dawley; Staphylococcal Infections/drug therapy; Structure-Activity Relationship

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Collection: 01-internacional Database: MEDLINE Main subject: Oxazoles / Pyrazoles / Pyrroles / Haemophilus influenzae / Moraxella catarrhalis / Anti-Bacterial Agents Limits: Animals Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 1998 Document type: Article Affiliation country: United States Country of publication: United States

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