Metabolism-dependent neutrophil cytotoxicity of amodiaquine: A comparison with pyronaridine and related antimalarial drugs.

Naisbitt, D J; Williams, D P; O'Neill, P M; Maggs, J L; Willock, D J; Pirmohamed, M; Park, B K

Naisbitt, D J; Williams, D P; O'Neill, P M; Maggs, J L; Willock, D J; Pirmohamed, M; Park, B K.

Affiliation

Naisbitt DJ; Department of Pharmacology and Therapeutics, The University of Liverpool, P.O. Box 147, Liverpool L69 3BX, U.K.

Chem Res Toxicol ; 11(12): 1586-95, 1998 Dec.

Article in En | MEDLINE | ID: mdl-9860505

Subject(s)

Amodiaquine/toxicity; Antimalarials/toxicity; Naphthyridines/toxicity; Neutrophils/drug effects; Neutrophils/metabolism; Adult; Amodiaquine/pharmacokinetics; Antimalarials/pharmacokinetics; Biotransformation; Cell Survival/drug effects; Glutathione/metabolism; Horseradish Peroxidase/metabolism; Humans; Hydrogen Peroxide/metabolism; In Vitro Techniques; Naphthyridines/pharmacokinetics; Oxidation-Reduction

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Collection: 01-internacional Database: MEDLINE Main subject: Amodiaquine / Naphthyridines / Antimalarials / Neutrophils Limits: Adult / Humans Language: En Journal: Chem Res Toxicol Journal subject: TOXICOLOGIA Year: 1998 Document type: Article Affiliation country: United kingdom Country of publication: United States

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