[S]-AR-R 15896AR-A novel anticonvulsant: acute safety, pharmacokinetic and pharmacodynamic properties.

Palmer, G C; Murray, R J; Cramer, C L; Stagnitto, M L; Knowles, M K; Freedman, L R; Eismann, M S; Mahmood, N; Balestra, M; Borrelli, A R; Hudzik, T J; McCarthy, D J

Palmer, G C; Murray, R J; Cramer, C L; Stagnitto, M L; Knowles, M K; Freedman, L R; Eismann, M S; Mahmood, N; Balestra, M; Borrelli, A R; Hudzik, T J; McCarthy, D J.

Affiliation

Palmer GC; Astra Arcus, Rochester, New York, USA.

J Pharmacol Exp Ther ; 288(1): 121-32, 1999 Jan.

Article in En | MEDLINE | ID: mdl-9862762

Subject(s)

Anticonvulsants/therapeutic use; Pyridines/therapeutic use; Seizures/prevention & control; 4-Aminopyridine; Animals; Anticonvulsants/pharmacokinetics; Anticonvulsants/pharmacology; Anticonvulsants/toxicity; Bicuculline; Electric Stimulation; Kainic Acid; Male; Mice; N-Methylaspartate/analogs & derivatives; Pentylenetetrazole; Picrotoxin; Pyridines/pharmacokinetics; Pyridines/pharmacology; Pyridines/toxicity; Rats; Rats, Sprague-Dawley; Seizures/chemically induced; Seizures/metabolism; Seizures, Febrile/drug therapy; Strychnine; Time Factors; Weaning

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Collection: 01-internacional Database: MEDLINE Main subject: Pyridines / Seizures / Anticonvulsants Type of study: Prognostic_studies Limits: Animals Language: En Journal: J Pharmacol Exp Ther Year: 1999 Document type: Article Affiliation country: United States Country of publication: United States

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