Asymmetric membrane capsules for osmotic drug delivery. I. Development of a manufacturing process.
J Control Release
; 57(1): 55-64, 1999 Jan 04.
Article
in En
| MEDLINE
| ID: mdl-9863039
ABSTRACT
This paper describes a novel non-disintegrating polymeric capsule and a manual and a semi-automatic process developed for its manufacture. The capsule wall was made by a phase inversion process in which the membrane structure was precipitated on stainless steel mold pins by dipping the mold pins into a coating solution containing a polymer-solvent-nonsolvent system followed by dipping into a quench solution. The resulting asymmetric membrane wall was composed of a thin dense region supported on a thicker porous region. The asymmetric membrane capsules can be filled with a blend of the active agent and excipients for use in osmotically modulated controlled drug delivery applications.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Drug Delivery Systems
/
Membranes, Artificial
Language:
En
Journal:
J Control Release
Journal subject:
FARMACOLOGIA
Year:
1999
Document type:
Article
Affiliation country:
United States