[Inhibitory effects of tachykinin receptor antagonists on leukotriene C4-induced cardiovascular responses in guinea pigs].
Yao Xue Xue Bao
; 31(12): 906-10, 1996.
Article
in Zh
| MEDLINE
| ID: mdl-9863223
ABSTRACT
This study is to determine whether sensory neuropeptides are involved in the cardiovascular effects of leukotriene C4 (LTC4). LTC4 (0.8 nmol.kg-1, i.v.) caused hypotensive response and increased Evans blue extravasation from the atria and ventricles in anaesthetized guinea pigs. CP-96345 (2.06 mumol.kg-1, i.v.), a tachykinin NK-1 receptor antagonist, and SR-48968 (1.66 mumol.kg-1, i.v.), an NK-2 receptor antagonist, partially inhibited LTC4-induced increase (46.6% and 37.5%, respectively) of dye extravasation from the atria of guinea pigs. Combination of CP-96345 and SR-48968 markedly inhibited LTC4-induced hypotension and increase of microvascular leakage in both atria and ventricles (58.1% and 54.1%, respectively), similar to the inhibition by ONO-1078 (0.06 mumol.kg-1, i.v.), a specific leukotriene antagonist. These results suggest that NK-1 and NK-2 receptors may be involved in the hypotension and the inflammation of heart induced by LTC4.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Piperidines
/
Benzamides
/
Biphenyl Compounds
/
Receptors, Neurokinin-2
/
Leukotriene C4
/
Neurokinin-1 Receptor Antagonists
Limits:
Animals
Language:
Zh
Journal:
Yao Xue Xue Bao
Year:
1996
Document type:
Article
Publication country:
CHINA
/
CN
/
REPUBLIC OF CHINA