A patient homozygous for mutation 20210A in the prothrombin gene with venous thrombosis and transient ischemic attacks of thrombotic origin.
Haematologica
; 83(11): 1050-1, 1998 Nov.
Article
in En
| MEDLINE
| ID: mdl-9864932
ABSTRACT
It is well established that genetic disorders interact with environmental factors to cause thrombotic diseases. Therefore, antithrombin, protein C, protein S deficiencies and the more recently described factor V Leiden and prothrombin mutations are currently been investigated to explain some thrombophilic states. We report the case of a 63-year-old man who developed two transient ischemic attacks and two years later an extensive femoro-iliac venous thrombosis. He was genotyped as FV R506Q negative and FII G20210A positive in homozygous state (FII 20210AA).
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Thrombophlebitis
/
Prothrombin
/
Ischemic Attack, Transient
/
Point Mutation
/
Thrombophilia
Type of study:
Etiology_studies
/
Risk_factors_studies
Limits:
Aged
/
Humans
/
Male
Language:
En
Journal:
Haematologica
Year:
1998
Document type:
Article