Thalidomide analogs and PDE4 inhibition.

Muller, G W; Shire, M G; Wong, L M; Corral, L G; Patterson, R T; Chen, Y; Stirling, D I

Muller, G W; Shire, M G; Wong, L M; Corral, L G; Patterson, R T; Chen, Y; Stirling, D I.

Affiliation

Muller GW; Celgene Corporation, Warren, NJ 07059 USA.

Bioorg Med Chem Lett ; 8(19): 2669-74, 1998 Oct 06.

Article in En | MEDLINE | ID: mdl-9873600

ABSTRACT

ABSTRACT

N-Phthaloyl 3-amino-3-arylpropionic acid analogs of thalidomide that are potent inhibitors of tumor necrosis factor-alpha are reported. These compounds were found to be potent inhibitors of phosphodiesterase 4.

Subject(s)

3',5'-Cyclic-AMP Phosphodiesterases/antagonists & inhibitors; Phosphodiesterase Inhibitors/pharmacology; Thalidomide/analogs & derivatives; Cyclic Nucleotide Phosphodiesterases, Type 4; Humans; Leukocytes, Mononuclear/drug effects; Leukocytes, Mononuclear/metabolism; Lipopolysaccharides/pharmacology; Phosphodiesterase Inhibitors/chemistry; Structure-Activity Relationship; Thalidomide/chemistry; Thalidomide/pharmacology; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha/antagonists & inhibitors

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Collection: 01-internacional Database: MEDLINE Main subject: Phosphodiesterase Inhibitors / Thalidomide / 3',5'-Cyclic-AMP Phosphodiesterases Limits: Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 1998 Document type: Article

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