Identification of a series of 1,2,3,4-tetrahydroisoquinolinyl-benzamides with potential anticonvulsant activity.

Chan, W N; Hadley, M S; Harling, J D; Herdon, H J; Jerman, J C; Orlek, B S; Stean, T O; Thompson, M; Upton, N; Ward, R W

Chan, W N; Hadley, M S; Harling, J D; Herdon, H J; Jerman, J C; Orlek, B S; Stean, T O; Thompson, M; Upton, N; Ward, R W.

Affiliation

Chan WN; SmithKline Beecham Pharmaceuticals, New Frontiers Science Park, Harlow, Essex, UK.

Bioorg Med Chem Lett ; 8(20): 2903-6, 1998 Oct 20.

Article in En | MEDLINE | ID: mdl-9873645

Subject(s)

Anticonvulsants/chemistry; Benzamides/chemistry; Quinolines/chemistry; Animals; Anticonvulsants/pharmacology; Anticonvulsants/therapeutic use; Benzamides/pharmacology; Benzamides/therapeutic use; Benzopyrans/pharmacology; Binding Sites; Mice; Models, Molecular; Quinolines/pharmacology; Quinolines/therapeutic use; Seizures/prevention & control; Structure-Activity Relationship

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Collection: 01-internacional Database: MEDLINE Main subject: Quinolines / Benzamides / Anticonvulsants Type of study: Diagnostic_studies Limits: Animals Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 1998 Document type: Article Affiliation country: United kingdom Country of publication: United kingdom

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