Quantitative neuronal c-fos and c-jun expression in Alzheimer's disease.
Neurobiol Aging
; 19(5): 393-400, 1998.
Article
in En
| MEDLINE
| ID: mdl-9880041
ABSTRACT
Apoptosis, or programmed cell death, has been proposed as a mechanism of neuropathology in Alzheimer's disease (AD). Activation of immediate early genes (IEG) c-jun and c-fos appears to be required for the initiation of apoptosis. Furthermore, the expression of c-jun is induced in cultured neurons that undergo beta-amyloid-mediated apoptosis suggesting a direct role for c-jun in the apoptosis of AD neurons. Using immunohistochemical methods, we calculated the average number of neuronal profiles per unit area expressing c-Jun and c-Fos within hippocampal regions CA1, CA2/3, and CA4 in postmortem brain samples from AD patients and age-matched non-AD patients. There was an increase in c-Jun-positive and c-Fos-positive neuronal profile density in nearly all AD hippocampal regions examined. In cerebellum there was no evidence of apoptosis as determined by using TUNEL technique, and negligible c-Jun labeling.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Proto-Oncogene Proteins c-jun
/
Proto-Oncogene Proteins c-fos
/
Alzheimer Disease
/
Neurons
Limits:
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Neurobiol Aging
Year:
1998
Document type:
Article
Affiliation country:
United States