Effects of pentachlorophenol, pentylenetetrazol and carnitine on mitochondria.
J UOEH
; 20(4): 315-22, 1998 Dec 01.
Article
in En
| MEDLINE
| ID: mdl-9883482
ABSTRACT
Pentachlorophenol (PCP) increased oxygen consumption and lowered the respiratory control ratio (RCR) in mitochondria from rat liver. These effects of PCP were lessened by 1 mM L-carnitine but not by D-carnitine. In contrast, up to 150 mM of pentylenetetrazol (PTZ) added at state 4 of respiration did not accelerate oxygen consumption. When mitochondria were incubated with 3.3 mM of PTZ, oxygen consumption, RCR and ADP/O ratio were all decreased. Moreover, these could not be suppressed even by high concentrations (-20 mM) of L-carnitine. Thus, while L-carnitine could suppress effects of PCP, it could not counteract PTZ in mitochondria. It appears that anticonvulsive effects of carnitine in PTZ-induced seizures may not be due to mitochondrial protection.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pentachlorophenol
/
Pentylenetetrazole
/
Mitochondria, Liver
/
Carnitine
/
Convulsants
Limits:
Animals
Language:
En
Journal:
J UOEH
Year:
1998
Document type:
Article
Affiliation country:
Japan