9-Hydroxyellipticine inhibits telomerase activity in human pancreatic cancer cells.
FEBS Lett
; 441(2): 318-21, 1998 Dec 18.
Article
in En
| MEDLINE
| ID: mdl-9883907
ABSTRACT
There is increasing interest in identifying potent inhibitors of telomerase because the enzyme plays a crucial role in the development of cellular immortality and carcinogenesis. We hypothesized that 9-hydroxyellipticine (9-HE), an antitumor alkaloid, would inhibit telomerase activity because the drug has a unique mechanism of inhibiting phosphorylation of mutant p53 protein via inhibition of protein kinases, thereby restoring wild-type p53 function. This study was conducted to examine the effect of 9-HE on telomerase activity in human pancreatic cancer cells with differing p53 gene status. 9-HE treatment at relatively high concentrations resulted in rapid, complete inhibition of telomerase activity, irrespective of the p53 status. We conclude that 9-HE may exert a strong inhibitory effect on telomerase activity possibly through inhibition of protein kinases rather than through restoration of functional wild-type p53.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pancreatic Neoplasms
/
Telomerase
/
Ellipticines
/
Enzyme Inhibitors
/
Antimetabolites, Antineoplastic
Limits:
Humans
Language:
En
Journal:
FEBS Lett
Year:
1998
Document type:
Article
Affiliation country:
Japan