Mutations and impaired function of LKB1 in familial and non-familial Peutz-Jeghers syndrome and a sporadic testicular cancer.

Ylikorkala, A; Avizienyte, E; Tomlinson, I P; Tiainen, M; Roth, S; Loukola, A; Hemminki, A; Johansson, M; Sistonen, P; Markie, D; Neale, K; Phillips, R; Zauber, P; Twama, T; Sampson, J; Järvinen, H; Mäkelä, T P; Aaltonen, L A

Ylikorkala, A; Avizienyte, E; Tomlinson, I P; Tiainen, M; Roth, S; Loukola, A; Hemminki, A; Johansson, M; Sistonen, P; Markie, D; Neale, K; Phillips, R; Zauber, P; Twama, T; Sampson, J; Järvinen, H; Mäkelä, T P; Aaltonen, L A.

Affiliation

Ylikorkala A; Hartman Institute and Biocentrum Helsinki and Department of Medical Genetics, Haartman Institute, PO Box 21, University of Helsinki, 00014 Helsinki, Finland.

Hum Mol Genet ; 8(1): 45-51, 1999 Jan.

Article in En | MEDLINE | ID: mdl-9887330

Subject(s)

Germ-Line Mutation; Peutz-Jeghers Syndrome/genetics; Protein Serine-Threonine Kinases/genetics; Testicular Neoplasms/genetics; AMP-Activated Protein Kinase Kinases; Alleles; Base Sequence; DNA/genetics; DNA Primers/genetics; Female; Humans; Male; Peutz-Jeghers Syndrome/enzymology; Point Mutation; Protein Serine-Threonine Kinases/deficiency; Protein Serine-Threonine Kinases/metabolism; RNA, Messenger/genetics; RNA, Messenger/metabolism; Sequence Deletion; Testicular Neoplasms/enzymology

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Collection: 01-internacional Database: MEDLINE Main subject: Testicular Neoplasms / Peutz-Jeghers Syndrome / Protein Serine-Threonine Kinases / Germ-Line Mutation Type of study: Prognostic_studies / Risk_factors_studies Limits: Female / Humans / Male Language: En Journal: Hum Mol Genet Journal subject: BIOLOGIA MOLECULAR / GENETICA MEDICA Year: 1999 Document type: Article Affiliation country: Finland Country of publication: United kingdom

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