A single intramuscular injection with an adenovirus-expressing IL-12 protects BALB/c mice against Leishmania major infection, while treatment with an IL-4-expressing vector increases disease susceptibility in B10.D2 mice.

Gabaglia, C R; Pedersen, B; Hitt, M; Burdin, N; Sercarz, E E; Graham, F L; Gauldie, J; Braciak, T A

Gabaglia, C R; Pedersen, B; Hitt, M; Burdin, N; Sercarz, E E; Graham, F L; Gauldie, J; Braciak, T A.

Affiliation

Gabaglia CR; Division of Immune Regulation, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA. claudia@liai.org

J Immunol ; 162(2): 753-60, 1999 Jan 15.

Article in En | MEDLINE | ID: mdl-9916695

Subject(s)

Adenoviridae/immunology; Genetic Vectors/immunology; Interleukin-12/immunology; Interleukin-4/immunology; Leishmania major/immunology; Leishmaniasis, Cutaneous/prevention & control; Vaccines, Synthetic/immunology; Adenoviridae/genetics; Animals; Disease Susceptibility; Extremities; Genetic Vectors/administration & dosage; Host-Parasite Interactions; Injections, Intramuscular; Interleukin-12/administration & dosage; Interleukin-12/biosynthesis; Interleukin-12/genetics; Interleukin-4/administration & dosage; Interleukin-4/biosynthesis; Interleukin-4/genetics; Leishmania major/growth & development; Leishmaniasis, Cutaneous/immunology; Leishmaniasis, Cutaneous/parasitology; Leukocyte Common Antigens/biosynthesis; Leukocyte Common Antigens/genetics; Lymph Nodes/parasitology; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Splenic Diseases/parasitology; Splenic Diseases/prevention & control

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Collection: 01-internacional Database: MEDLINE Main subject: Vaccines, Synthetic / Adenoviridae / Interleukin-4 / Leishmaniasis, Cutaneous / Leishmania major / Interleukin-12 / Genetic Vectors Limits: Animals Language: En Journal: J Immunol Year: 1999 Document type: Article Affiliation country: United States Country of publication: United States

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