[Current studies of combined radiotherapy-hormone therapy in localized and locally advanced prostatic cancers]. / Données actuelles de l'association radiothérapie-hormonothérapie dans les cancers de la prostate localisés et localement évolués.
Cancer Radiother
; 2(6): 783-6, 1998 Dec.
Article
in Fr
| MEDLINE
| ID: mdl-9922789
In locally advanced prostate cancer three clinical randomized trials have shown that external irradiation combined with LHRH analogue with or without antiandrogen improved survival: disease-free survival, local recurrence-free survival, metastasis-free survival (P < 0.001). EORTC trial 22863 alone has shown a significant improvement of overall survival (P = 0.001), with an LHRH analogue (goserilin acetate, zoladex) started the first day of irradiation and followed every 4 weeks for 3 years; for RTOG trial 85-31 the same LHRH analogue started during the last week of irradiation and given until relapse increases survival of patients with poor differentiated tumours with gleason score ranging from 8 to 10 (P = 0.03). In locally confined prostate carcinoma randomized trials are ongoing to assess the impact of conventional irradiation or three dimensional conformal radiotherapy with or without adjuvant hormonotherapy.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Prostatic Neoplasms
/
Radiation-Sensitizing Agents
/
Antineoplastic Agents, Hormonal
Type of study:
Clinical_trials
/
Risk_factors_studies
Limits:
Humans
/
Male
Language:
Fr
Journal:
Cancer Radiother
Journal subject:
NEOPLASIAS
/
RADIOTERAPIA
Year:
1998
Document type:
Article
Affiliation country:
France
Country of publication:
France