Prenyltransferase inhibitors induce apoptosis in proliferating thyroid cells through a p53-independent CrmA-sensitive, and caspase-3-like protease-dependent mechanism.

Vitale, M; Di Matola, T; Rossi, G; Laezza, C; Fenzi, G; Bifulco, M

Vitale, M; Di Matola, T; Rossi, G; Laezza, C; Fenzi, G; Bifulco, M.

Affiliation

Vitale M; Dipartimento di Biologia e Patologia Cellulare e Molecolare, Università Federico II, Naples, Italy.

Endocrinology ; 140(2): 698-704, 1999 Feb.

Article in En | MEDLINE | ID: mdl-9927296

Subject(s)

Apoptosis/physiology; Caspases/physiology; Dimethylallyltranstransferase/antagonists & inhibitors; Serpins/physiology; Thyroid Gland/physiology; Tumor Suppressor Protein p53/physiology; Viral Proteins; Apoptosis/drug effects; Benzamides/pharmacology; Cell Division/physiology; Cell Line; Cysteine Proteinase Inhibitors/pharmacology; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors/pharmacology; Lovastatin/pharmacology; Methionine/analogs & derivatives; Methionine/pharmacology; Thyroid Gland/cytology; Thyroid Gland/drug effects

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Collection: 01-internacional Database: MEDLINE Main subject: Thyroid Gland / Viral Proteins / Serpins / Tumor Suppressor Protein p53 / Apoptosis / Caspases / Dimethylallyltranstransferase Type of study: Diagnostic_studies Limits: Humans Language: En Journal: Endocrinology Year: 1999 Document type: Article Affiliation country: Italy

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