Glial glutamate transport as target for nitric oxide: consequences for neurotoxicity.
Prog Brain Res
; 118: 241-51, 1998.
Article
in En
| MEDLINE
| ID: mdl-9932446
ABSTRACT
Overwhelming evidence suggest that accumulations of extracellular glutamate are toxic to neurons. It has also been proposed that astrocytes protect neurons from glutamate toxicity by removal of glutamate from extracellular space. By using co-cultures of hippocampal neurons and astrocytes, we studied the influence of astrocytes on neuronal excitotoxicity. Moreover, we evaluated the role of nitric oxide and pro-inflammatory cytokines on astrocytic glutamate transport.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Neuroglia
/
Glutamic Acid
/
Nervous System Physiological Phenomena
/
Nitric Oxide
Limits:
Animals
/
Humans
Language:
En
Journal:
Prog Brain Res
Year:
1998
Document type:
Article
Affiliation country:
United States