Interleukin-12 induces sustained activation of multiple host inflammatory mediator systems in chimpanzees.

Lauw, F N; Dekkers, P E; te Velde, A A; Speelman, P; Levi, M; Kurimoto, M; Hack, C E; van Deventer, S J; van der Poll, T

Lauw, F N; Dekkers, P E; te Velde, A A; Speelman, P; Levi, M; Kurimoto, M; Hack, C E; van Deventer, S J; van der Poll, T.

Affiliation

Lauw FN; Laboratory of Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands. F.N.Lauw@AMC.UVA.NL

J Infect Dis ; 179(3): 646-52, 1999 Mar.

Article in En | MEDLINE | ID: mdl-9952371

Subject(s)

Chemokines/blood; Cytokines/blood; Interleukin-12/pharmacology; Animals; Blood Coagulation Factors/metabolism; Chemokine CCL2/blood; Chemokine CCL4; Chemokines/biosynthesis; Cytokines/biosynthesis; Dose-Response Relationship, Drug; Fibrinolysis; Humans; Inflammation/immunology; Injections, Intravenous; Interferon-gamma/blood; Interleukin-12/administration & dosage; Interleukin-12/blood; Interleukin-15/blood; Interleukin-18/blood; Macrophage Inflammatory Proteins/blood; Neutrophils/physiology; Pan troglodytes; Recombinant Proteins/administration & dosage; Recombinant Proteins/pharmacology; Time Factors; Tissue Plasminogen Activator/blood

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Collection: 01-internacional Database: MEDLINE Main subject: Cytokines / Interleukin-12 / Chemokines Limits: Animals / Humans Language: En Journal: J Infect Dis Year: 1999 Document type: Article Affiliation country: Netherlands

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