The 21-aminosteroid U-74389F attenuates hyperexpression of GAP-43 and NADPH-diaphorase in the spinal cord of wobbler mouse, a model for amyotrophic lateral sclerosis.

González Deniselle, M C; González, S L; Lima, A E; Wilkin, G; De Nicola, A F

González Deniselle, M C; González, S L; Lima, A E; Wilkin, G; De Nicola, A F.

Affiliation

González Deniselle MC; Laboratory of Neuroendocrine Biochemistry, Instituto de Biologia y Medicina Experimental, Buenos Aires, Argentina.

Neurochem Res ; 24(1): 1-8, 1999 Jan.

Article in En | MEDLINE | ID: mdl-9973230

Subject(s)

Amyotrophic Lateral Sclerosis/metabolism; Antioxidants/pharmacology; Dihydrolipoamide Dehydrogenase/genetics; GAP-43 Protein/genetics; Gene Expression Regulation/drug effects; Motor Neurons/metabolism; Pregnatrienes/pharmacology; Spinal Cord/metabolism; Amyotrophic Lateral Sclerosis/genetics; Animals; Dihydrolipoamide Dehydrogenase/biosynthesis; Disease Models, Animal; Female; GAP-43 Protein/biosynthesis; Humans; Male; Mice; Mice, Neurologic Mutants; Motor Neurons/cytology; Motor Neurons/pathology; Spinal Cord/cytology; Spinal Cord/pathology

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Collection: 01-internacional Database: MEDLINE Main subject: Pregnatrienes / Spinal Cord / Gene Expression Regulation / GAP-43 Protein / Amyotrophic Lateral Sclerosis / Dihydrolipoamide Dehydrogenase / Motor Neurons / Antioxidants Limits: Animals / Female / Humans / Male Language: En Journal: Neurochem Res Year: 1999 Document type: Article Affiliation country: Argentina Country of publication: United States

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