Urea production and salvage during pregnancy in normal Jamaica women
Am J Clin Nutr
; 60(3): 341-6, Sept. 1994.
Article
| MedCarib
| ID: med-10776
Responsible library:
JM3.1
Localization: JM3.1; RC620.A1A4
ABSTRACT
The pattern of aggregated nitrogen demand during pregnancy and the fetal and maternal components are unclear. Excess demand enhances efficiency of nitrogen utilization. Urea salvage contributes to enhanced efficiency. Dietary protein intake, urea production, and salvage of urea nitrogen were measured in eight nonpregnant control subjects, and trimesterly in nine pregnant women. Production was measured after prime-intermittent intravenous doses of [15N15N]-urea by dilution of label in urinary urea. Dietary protein intake was greater in trimester 1 than in nonpregnant women (167 ñ 36 vs 224 ñ 60 mg N.kg-1.d-1), and increased further in trimester 2 (266 ñ 59 mg N.kg-1.d-1). Urea production was not higher during pregnancy. Despite higher protein intake urea salvage was higer in pregnancy (40 ñ 24 nonpregnant vs 77 ñ 23, 61 ñ 31, and 51 ñ 12 mg N.kg-1.d-1). Therefore, the demand-supply gap for nitrogen was greatest early in pregnancy when fetoplacental growth is slowest, and implies heightened maternal demand (AU)
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Collection:
International databases
Database:
MedCarib
Main subject:
Urea
/
Pregnancy
/
Dietary Proteins
/
Nitrogen
Type of study:
Observational study
Limits:
Adult
/
Female
/
Humans
Country/Region as subject:
English Caribbean
/
Jamaica
Journal:
Am J Clin Nutr
Year:
1994
Document type:
Article