Red cell antibodies in patients with homozygous sickle cell disease: a comparison of patients in Jamaica and the United Kingdom
Br J Haematol
; 113(3): 661-5, Jun. 2001. tab, gra
Article
in English
| MedCarib
| ID: med-109
Responsible library:
JM3.1
Localization: JM3.1; RB145.A1B7
ABSTRACT
The transfusion history and frequency of red cell antibodies in patients with homozygous sickle cell (SS) disease have been compared in 190 subjects from the Jamaican cohort study and 37 patients attending a sickle cell clinic in Manchester, England. The proportion of patients transfused did not differ between the groups although the number of units transfused and the frequency of red cell antibodies were significantly greater in the Manchester group. Immune antibodies occurred in three Jamaicans (2.6 percent of those transfused) and 16 UK subjects (76 percent of those transfused). Multiple antibodies occurred in 10 (63 percent) UK subjects but in no Jamaicans. Indications for transfusion also differed between the groups, Jamaican patients typically receiving 1-2 units for acute anaemia or acute chest syndrome, whereas UK patients frequently had multiple transfusions in preoperative exchange or prophylaxis programmes. The greater red cell alloimmunization among UK patients probably reflects both the greater use of transfusion and the disparity between donor and recipient populations in the UK. (AU)
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Collection:
International databases
Database:
MedCarib
Main subject:
Blood Group Antigens
/
Blood Transfusion
/
Anemia, Sickle Cell
/
Isoantibodies
Type of study:
Etiology study
/
Incidence study
/
Observational study
/
Risk factors
Limits:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
Country/Region as subject:
English Caribbean
/
Europa
/
Jamaica
Language:
English
Journal:
Br J Haematol
Year:
2001
Document type:
Article