Your browser doesn't support javascript.
loading
Hypoglycemic and Hepatoprotective activity of fermented fruit juice of Morinda citrifolia (Noni) in diabetic rats
Nayak, B. Shivananda; Marshall, Julien R. ; Isitor, Godwin ; Adogwa, Andrew .
Affiliation
  • Nayak, B. Shivananda; The University of the West Indies. Faculty of Medical Sciences. Department of Preclinical Sciences. St. Augustine. Trinidad and Tobago
  • Marshall, Julien R. ; The University of the West Indies. Faculty of Medical Sciences. Department of Preclinical Sciences. St. Augustine. Trinidad and Tobago
  • Isitor, Godwin ; The University of the West Indies. Faculty of Medical Sciences. Department of Preclinical Sciences. St. Augustine. Trinidad and Tobago
  • Adogwa, Andrew ; The University of the West Indies. Faculty of Medical Sciences. Department of Preclinical Sciences. St. Augustine. Trinidad and Tobago
Article in English | MedCarib | ID: med-17584
Responsible library: TT5
ABSTRACT
Morinda citrifolia is a medicinal plant used to treat diabetes and liver diseases. The fermented fruit juice of the M. Citrifolia (optical density = 1.25) was used to study the hypoglycemic and hepatoprotective properties in diabetes-induced rats. The rats were randomly distributed into 4 groups (control, diabetic experimental, diabetic standard, and diabetic untreated) of 6 each. Diabetes was induced by administering Streptozotocin (50 mg/kg body weight). Fasting blood glucose, body mass, liver tissue glycogen content, and the extent of liver degeneration were assessed. Diabetic experimental animals were treated with M. citrifolia juice (2 ml/kg, twice a day) and diabetic standard with reference hypoglycemic drug, glibenclamide orally for 20 days. Both the groups exhibited a significant reduction in blood glucose level of 150 mg/dl ñ15.88 and 125 mg/dl ñ3.89, respectively, as compared to diabetic untreated with FBS = 360.0 mg/dl ñ15.81, (P < .003). On 10th day of experiment, diabetic experimental animals exhibited a decrease in body mass (10.2 g, 5.11%) which increased significantly by the 20th day (6 g, 3.0%, P < .022). Histological study of liver tissue obtained from untreated diabetic animals revealed significant fatty degeneration as compared to other three groups. The data of this study proved the hypoglycemic and hepatoprotective activity of M. citrifolia.
Subject(s)
Full text: Available Collection: International databases Database: MedCarib Main subject: Trinidad and Tobago / Morinda / Diabetes Mellitus / Hypoglycemic Agents Limits: Animals Country/Region as subject: English Caribbean / Trinidad and Tobago Language: English Journal: Evidence-based complementary and alternative medicine : eCAM Year: 2011 Document type: Article Institution/Affiliation country: The University of the West Indies/Trinidad and Tobago
Full text: Available Collection: International databases Database: MedCarib Main subject: Trinidad and Tobago / Morinda / Diabetes Mellitus / Hypoglycemic Agents Limits: Animals Country/Region as subject: English Caribbean / Trinidad and Tobago Language: English Journal: Evidence-based complementary and alternative medicine : eCAM Year: 2011 Document type: Article Institution/Affiliation country: The University of the West Indies/Trinidad and Tobago
...