Study on the efficacy of Leptospira vaccines developed from serovars isolated from Trinidad and comparison with commercial vaccines using a hamster model
Vaccine
; 28(33): 5421-5426, Jun. 19 2010. tab, graf
Article
in English
| MedCarib
| ID: med-17679
Responsible library:
TT5
ABSTRACT
A hamster model was used to determine the efficacy of commercially prepared canine vaccines against Leptospira serovars circulating in Trinidad and to assess the effectiveness of killed whole-cell vaccines prepared from local isolates. The local isolates used for vaccine preparation and challenge were isolates of serovars Copenhageni and Mankarso obtained from a local dog and rodent. Their estimated lethal dose-50 (LD(50)) were 5 and 10 organisms, respectively and clinical signs observed on infection were consistent with leptospirosis. An unvaccinated control group of hamsters and other groups of hamsters that had been vaccinated with 3 doses of (i) in-house whole-cell Copenhageni vaccine, (ii) in-house whole-cell Mankarso vaccine, (iii) commercial vaccine Brand A or (iv) commercial vaccines Brand B were challenged with 1000 times the LD(50) of the respective challenge serovar. The most commonly used commercial vaccine (Brand A) did not offer protection to challenged hamsters, whereas Brand B facilitated the renal carrier state of the Leptospira organism. In contrast the whole-cell vaccines developed from local strains of serovars Copenhageni and Mankarso, protected all hamsters tested from both clinical disease and renal carrier states.
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Collection:
International databases
Health context:
Sustainable Health Agenda for the Americas
/
SDG3 - Health and Well-Being
Health problem:
Goal 10: Communicable diseases
/
Target 3.3: End transmission of communicable diseases
Database:
MedCarib
Main subject:
Trinidad and Tobago
/
Vaccines
/
Leptospira
/
Leptospirosis
Limits:
Animals
/
Humans
Country/Region as subject:
English Caribbean
/
Trinidad and Tobago
Language:
English
Journal:
Vaccine
Year:
2010
Document type:
Article
Institution/Affiliation country:
The University of The West Indies/Trinidad and Tobago