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High prevalence of diabetes mellitus in a cohort of Trinidadian patients with chronic obstructive pulmonary disease
In. Caribbean Public Health Agency. Caribbean Public Health Agency: 60th Annual Scientific Meeting. Kingston, The University of the West Indies. Faculty of Medical Sciences, 2015. p.[1-75]. (West Indian Medical Journal Supplement).
Monography in English | MedCarib | ID: med-17974
Responsible library: TT2.1
ABSTRACT

OBJECTIVE:

To define the prevalence of diabetes mellitus (DM) in a cohort of Trinidadian chronic obstructive pulmonary disease (COPD) patients, and investigate its relationship to lung function, quality of life, and depression. DESIGN AND

METHODS:

Anthropometric and spirometric data were obtained from 108 COPD (91 males) patients from Trinidad chest clinics, who also had HbA1c test results. Questionnaires on quality of life St. George’s Respiratory questionnaire ({SGRQ} and COPD Assessment Test {CAT}) and depression (Center for Epidemiologic Studies Depression Scale {CES-D & CESD-R}) were administered, and an interview conducted.

RESULTS:

Mean (SD) age 67.4 (11.0) years. Median (IQR) HbA1c 6.1 (5.7, 6.7) %. HbA1c values were obtained for 105 patients of whom 40% had diabetes, and 40% pre-diabetes. Diabetics had a greater (p=0.001) median (IQR) BMI [27.3 (24.1, 30.4)] than non-diabetics [24.2 (21.2, 27.2)]. Patients with at least one chest infection/exacerbation in the past year had increasing CAT & SGRQ Total (p<0.001), and CES-D & CESD-R (p≤0.013) scores. CAT and SGRQ total scores were negatively related to lung function and Global Initiative for Chronic Obstructive Lung Disease (GOLD) stages (p<0.001). All lung function parameters, except Forced expiratory volume/Forced vital capacity (FEV1/FVC), decreased with increasing CES-D and CESD-R scores (p<0.05). CAT & SGRQ correlated well with CES-D & CESD-R scores (p<0.001). Intravenous corticosteroid use was positively associated with HbA1c (p=0.043). Dosage of inhaled corticosteroids was associated with lower FEV1 (p=0.034) and higher SGRQ & CAT (p≤0.048). FVC % predicted was negatively related to HbA1c (p=0.033).

CONCLUSION:

The prevalence of DM in the COPD patients was 40%; however no significant correlations of DM to outcome measures were observed. Patients with worse quality of life due poor lung function were more depressed.
Subject(s)
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Collection: International databases Database: MedCarib Main subject: Quality of Life / Respiratory Physiological Phenomena / Trinidad and Tobago / Prevalence / Pulmonary Disease, Chronic Obstructive / Depression / Diabetes Mellitus Type of study: Prevalence study / Prognostic study / Risk factors Aspects: Patient-preference Country/Region as subject: English Caribbean / Trinidad and Tobago Language: English Journal: West Indian Medical Journal Supplement Year: 2015 Document type: Monography
Search on Google
Collection: International databases Database: MedCarib Main subject: Quality of Life / Respiratory Physiological Phenomena / Trinidad and Tobago / Prevalence / Pulmonary Disease, Chronic Obstructive / Depression / Diabetes Mellitus Type of study: Prevalence study / Prognostic study / Risk factors Aspects: Patient-preference Country/Region as subject: English Caribbean / Trinidad and Tobago Language: English Journal: West Indian Medical Journal Supplement Year: 2015 Document type: Monography
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