Apolipoprotein-E genotype distribution in consecutive Trinidadian newborns of African and Indian descent: comparisons with other populations and relations of the apolipoprotein-E genotype with plasma lipid indices
West Indian med. j
; 47(suppl. 2): 36-7, Apr. 1998.
Article
in English
| MedCarib
| ID: med-1861
Responsible library:
JM3.1
Localization: JM3.1; R18.W4
ABSTRACT
Trinidadian Indians and Africans have different coronary artery disease (CAD) incidences. We determined apolipoprotein-E (apo-E) genotypes, and umbilical plasma cholesterol, triglycerides, apo-A1, apo-B and lipoprotein(a) [Lp(a) in 294 consecutive newborns in Trinidad. We calculate the apo-B/apo-A1 ratio and an adapted "lipid tetrad index" (i.e cholesterol*triglycerides*Lp(a)/apo-A1). Apo-E genotype distributions of Trinidadian Africans (allele frequencies apo-e2e3e4=10.466.423.2 percent) and Indians(e2e3e4=3.583.113.4 percent) were different. The apo-E genotype distribution of Trinidadian Africans resembles to a certain extent that of their counterpart in Curacao and Sudan, but not that of cuonterparts in Nigeria and the USA.(AU)
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Collection:
International databases
Database:
MedCarib
Main subject:
Apolipoproteins E
/
Coronary Disease
Type of study:
Etiology study
/
Prognostic study
/
Risk factors
Limits:
Humans
Country/Region as subject:
English Caribbean
/
Trinidad and Tobago
Language:
English
Journal:
West Indian med. j
Year:
1998
Document type:
Article