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The influence of persistent hyperglycaemia of hyperfibrinogenaemia and hyperviscosity in diabetes mellitus
Reid, Harvey L; Vigilance, Jacqueline E; Wright Pascoe, Rosemarie; Choo Kang, Eric.
Affiliation
  • Reid, Harvey L; University of the West Indies, Mona, Jamaica. Department of Basic Medical Sciences (Physiology Section), e mail: hlreid@uwimona.edu.jm
  • Vigilance, Jacqueline E; University of the West Indies, Mona, Jamaica. Department of Basic Medical Sciences (Physiology Section)
  • Wright Pascoe, Rosemarie; University of the West Indies, Mona, Jamaica. Department of Medicine
  • Choo Kang, Eric; University of the West Indies, Mona, Jamaica. Department of Pathology
West Indian Med. J ; 49(4): 281-4, Dec. 2000. tab, gra
Article in En | MedCarib | ID: med-468
Responsible library: JM3.1
Localization: JM3.1; R18.W4
ABSTRACT
The effect of hyperglycaemia on hyperfibrinogenaemia and its consequence on plasma viscosity was investigated in 69 diabetic patients during the course of hypoglycaemic treatment. Glycaemic control was assessed by measurement of glycosylated haemoglobin (HbA). Plasma fibrinogen concentration (PFC) was determined by a clot-weight method. The relative plasma viscosity (RPV) was measured by capillary viscometry. The mean PFC and RPV were significantly (p<0.001) elevated in the diabetic patients as compared with a non-diabetic control group. Both PFC and RPV showed a distinct, step-wise increase with progressively poorer glycaemic control. The data strongly indicate that persistent hyperglycaemia is associated with a frank hyperfibrinogenaemia and hyperviscous plasma in most of the diabetic patients studied. These abnormal haemorrheological changes could impact adversely on both the haemostatic process and circulation in diabetic patients(Au)
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Collection: 01-internacional Database: MedCarib Main subject: Blood Viscosity / Fibrinogen / Diabetes Mellitus / Hyperglycemia Limits: Adult / Aged / Female / Humans / Male Language: En Journal: West Indian Med. J Year: 2000 Document type: Article
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Collection: 01-internacional Database: MedCarib Main subject: Blood Viscosity / Fibrinogen / Diabetes Mellitus / Hyperglycemia Limits: Adult / Aged / Female / Humans / Male Language: En Journal: West Indian Med. J Year: 2000 Document type: Article