Risk of Zika virus-associated birth defects in congenital confirmed cases in the Brazilian Amazon
Rev Panam Salud Publica
; 44, sept. 2020
Article
in English
| PAHO-IRIS
| ID: phr-52652
Responsible library:
US1.1
ABSTRACT
Objective. To establish the risk of microcephaly in neonates born to women infected with ZIKV during pregnancy. Methods. A cohort of laboratory-confirmed ZIKV cases of congenital infections (109 mothers infected during pregnancy and 101 newborns) among 308 suspect cases was followed in Belem, Pará, Brazil, from October 2015 to December 2017. Results. A microcephaly risk of 1.98% (95% CI 0.54-6.93%) was found, or 2 cases among the 101 neonates infected with ZIKV during pregnancy. 72% of the pregnant women had ZIKV infection confirmed by RT-qPCR during gestation. Conclusions. Results showed a low incidence of ZIKV-associated birth defects, stillbirth, and miscarriage, which contrasts with previous studies in other Brazilian regions. Previous exposure to yellow fever vaccine and/ or multiserotype DENV infection could be implicated in the protection from ZIKV congenital infection.
Full text:
Available
Collection:
Databases of international organizations
Health context:
Neglected Diseases
Health problem:
Dengue
Database:
PAHO-IRIS
Main subject:
Pregnancy Complications
/
Pregnancy Complications, Infectious
/
Brazil
/
Zika Virus Infection
/
Microcephaly
Type of study:
Etiology study
/
Risk factors
Country/Region as subject:
South America
/
Brazil
Language:
English
Year:
2020
Document type:
Article