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Clinical characteristics and early outcomes in patients with COVID-19 treated with tocilizumab at a United States academic center
Casey Allison Rimland; Camille E Morgan; Griffin J Bell; Min K Kim; Tanner Hedrick; Ashley Marx; Brian Bramson; Heidi Swygard; Sonia Napravnik; John L Schmitz; Shannon S Carson; William A Fischer; Joseph J Eron; Cynthia L Gay; Jonathan B Parr.
Affiliation
  • Casey Allison Rimland; Medical Scientist Training Program, University of North Carolina at Chapel Hill (UNC), Chapel Hill, NC
  • Camille E Morgan; Medical Scientist Training Program, University of North Carolina at Chapel Hill (UNC), Chapel Hill, NC; Department of Epidemiology, UNC Gillings School of Glob
  • Griffin J Bell; Department of Epidemiology, UNC Gillings School of Global Public Health, Chapel Hill, NC
  • Min K Kim; Division of Infectious Diseases, Department of Medicine, UNC School of Medicine, Chapel Hill, NC
  • Tanner Hedrick; Department of Pharmacy, UNC Medical Center, Chapel Hill, NC
  • Ashley Marx; Department of Pharmacy, UNC Medical Center, Chapel Hill, NC
  • Brian Bramson; Division of Infectious Diseases, Department of Medicine, UNC School of Medicine, Chapel Hill, NC
  • Heidi Swygard; Division of Infectious Diseases, UNC School of Medicine, Chapel Hill, NC, USA
  • Sonia Napravnik; Department of Epidemiology, UNC Gillings School of Global Public Health, Chapel Hill, NC; Division of Infectious Diseases, Department of Medicine, UNC School of
  • John L Schmitz; Department of Pathology and Laboratory Medicine, UNC School of Medicine, Chapel Hill, NC
  • Shannon S Carson; Division of Pulmonary Diseases and Critical Care Medicine, Department of Medicine, UNC School of Medicine, Chapel Hill, NC
  • William A Fischer; Division of Pulmonary Diseases and Critical Care Medicine, Department of Medicine, UNC School of Medicine, Chapel Hill, NC
  • Joseph J Eron; Division of Infectious Diseases, Department of Medicine, UNC School of Medicine, Chapel Hill, NC
  • Cynthia L Gay; Division of Infectious Diseases, Department of Medicine, UNC School of Medicine, Chapel Hill, NC
  • Jonathan B Parr; Division of Infectious Diseases, Department of Medicine, UNC School of Medicine, Chapel Hill, NC
Preprint in En | PREPRINT-MEDRXIV | ID: ppmedrxiv-20100404
ABSTRACT
We describe early outcomes in 11 COVID-19 patients treated with the IL-6 receptor inhibitor tocilizumab. While C-reactive protein decreased, neither clinical improvement nor reduced temperature or oxygen requirements was observed in most patients. Our findings contrast with prior reports and raise questions about tocilizumab use in severe COVID-19.
License
cc_by_nc_nd
Full text: 1 Collection: 09-preprints Database: PREPRINT-MEDRXIV Type of study: Prognostic_studies Language: En Year: 2020 Document type: Preprint
Full text: 1 Collection: 09-preprints Database: PREPRINT-MEDRXIV Type of study: Prognostic_studies Language: En Year: 2020 Document type: Preprint