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Convalescent plasma in the management of moderate COVID-19 in India: An open-label parallel-arm phase II multicentre randomized controlled trial (PLACID Trial)
Anup Agarwal; Aparna Mukherjee; Gunjan Kumar; Pranab Chatterjee; Tarun Bhatnagar; Pankaj Malhotra; B Latha; Sunita Bundas; Vivek Kumar; Ravi Dosi; Janak Kumar Khambholja; Rosemarie de Souza; Raja Rao Mesipogu; Saurabh Srivastava; Simmi Dube; Kiran Chaudhary; Subash S; S. Anbuselvi Mattuvar K; V Rajendran; A Sundararajaperumal; P Balamanikandan; R S Uma Maheswari; R Jayanthi; S Ragunanthanan; Sudhir Bhandari; Ajeet Singh; Ashok Pal; Anjali Handa; Govind Rankawat; Ketan Kargirwar; Joyce Regi; Darshana Rathod; Edwin Pathrose; Nirankar Bhutaka; Mayur H Patel; Rahul J Verma; Kamal Malukani; Shivani Patel; Apurv Thakur; Satish Joshi; Rashmi Kulkarni; Nilay N Suthar; Nehal M Shah; Hemang M Purohit; Cherry K Shah; Monila N Patel; Saket Shah; Smit H Shah; Tehsim Memon; Vishal R Beriwala; Kusum Jashnani; Fatema Ezzy; Simran Agrawal; Rakesh Bhadade; Atish M N; Tushar Madke; Vikash Kavishwar; Ramesh Waghmare; Nitin Valvi; B Thrilok Chander; A Vinaya Sekhar; Akhilesh Kumar Maurya; K Hemanth; K Nagamani; K Sudha; T Ravi Chandra; K Tushara Rao; J Vyshnavi; Rashmi Upadhyay; Shalini Bahadur; Rambha Pathak; Shikha Seth; Rakesh Gupta; Rita Saxena; Preksha Dwivedi; Reeni Malik; Deepti Chourasia; Jaya Lalwani; UM Sharma; JL Marko; Amit Suri; Vijay Kumar; Rajnish Kaushik; Parul Kodan; Bhabani Prasad Acharya; Kuldeep Kumar Gaur; Anubhav Gupta; Prerna Sachdeva; Shruti Dogra; Aikaj Jindal; M Joseph John; Avtar Singh Dhanju; Ranjana Khetrepal; Neeraj Sharma; Neetu Kukar; Divya Kavita; Rajesh Kumar; Rajesh Mahajan; Gurpreet Singh; Jaspreet Kaur; Raminder Pal Singh; Rajni Bassi; Swapneil Parikh; Om Shrivastav; Jayanthi Shastri; Maherra Desai; Shreevatsa Udupa; Varun A Bafna; Vijay Barge; Rajendra Madane; Sheetal Yadav; Sanjeev Mishra; Archana Bajpayee; M K Garg; G K Bohra; Vijaylakshmi Nag; Puneeth Babu Anne; Mohd Nadeem; Pallavi Singh; Ram Niwas; Niranjan Shiwaji Khaire; Rattiram Sharma; Mini p Singh; Naresh Sachdeva; Suchet Sachdev; Rekha Hans; Vikas Suri; L N Yaddanapudi; PVM Lakshmi; Neha Singh; Divendu Bhushan; Neeraj Kumar; Muralidhar Tambe; Sonali Salvi; Nalini Kadgi; Shashikala Sangle; Leena Nakate; Samir Joshi; Rajesh Karyakarte; Suraj Goyanka; Nimisha Sharma; Nikhil Verma; Asim Das; Monika Bahl; Nitya Wadhwa; Shreepad Bhat; Shweta Deshmukh; Vrushali Wagh; Atul Kulkarni; Tanvi Yardi; Ram S Kalgud; Purushottam Reddy; Kavitha Yevoor; Prashanth Gajula; Vivek Maleyur; Medini S; Mohith HN; Anil Gurtoo; Ritika Sud; Sangeeta Pahuja; Anupam Prakash; Parijat Gogoi; Shailja Shukla; D Himanshu Reddy; Tulika Chandra; Saurabh Pandey; Pradeep Maurya; Ali Wahid; Vivek Kumar; Kamlesh Upadhyay; Nidhi Bhatnagar; Nilima Shah; Mamta Shah; Tarak Patel; Ram Mohan Jaiswal; Ashish Jain; Shweta Sharma; Puneet Rijhwani; Naveen Gupta; Tinkal C Patel; Mahesh G Solu; Jitendra Patel; Yash R Shah; Mayur Jarag; Varsha Godbole; Meenakshi Shah; Rikin Raj; Irfan Nagori; Pramod R Jha; Arti D Shah; Gowtham Yeeli; Archit Jain; Rooppreet Kaur Gill; KV Sreedhar Babu; B Suresh Babu; Alladi Mohan; B Vengamma; K Chandra Sekhar; Srinivasulu Damam; K Narsimhulu; C Aparna; G Baleswari; Ravindranath Reddy K; P Chandrasekhar; Sunil Jodharam Panjwani; Pankaj J Akholkar; Kairavi Parthesh Joshi; Pragnesh H Shah; Manish Barvaliya; Milind Baldi; Ashok Yadav; Manoj Gupta; Nitin Rawat; Dilip Chawda; M Natarajan; M Sintha; David Pradeep Kumar; Fathhur Rabbani; Vrushali Khirid Khadke; Dattatray Patki; Sonali Marathe; Clyde D Souza; Vipul Tadha; Satyam Arora; Devendra Kumar Gupta; Seema Dua; Nitu Chauhan; Ajeet Singh Chahar; Joy John Mammen; Snehil Kumar; Dolly Daniel; Ravindraa Singh; Venkatesh Dhat; Yogesh Agarwal; Sohini Arora; Ashish Pathak; Manju Purohit; Ashish Sharma; Jayashree Sharma; Manisha Madkaikar; Kavita Joshi; Reetika Malik Yadav; Swarupa Bhagwat; Niteen D Karnik; Yojana A Gokhale; Leena Naik; Sangita Margam; Santasabuj Das; Alka Turuk; V Saravana Kumar; K Kanagasabai; R Sabarinathan; Gururaj Deshpande; Sharda Sharma; Rashmi Gunjikar; Anita Shete; Darpan Phagiwala; Chetan Patil; Snehal Shingade; Kajal Jarande; Himanshu Kaushal; Pragya Yadav; Gajanan Sapkal; Priya Abraham.
Affiliation
- Anup Agarwal; Clinical Trial & Health Systems Research Unit, Indian Council of Medical Research (ICMR), New Delhi, India
- Aparna Mukherjee; Clinical Trial & Health Systems Research Unit, Indian Council of Medical Research (ICMR), New Delhi, India
- Gunjan Kumar; Clinical Trial & Health Systems Research Unit, Indian Council of Medical Research (ICMR), New Delhi, India
- Pranab Chatterjee; Scientist B, Translational Global Health Policy and Research Cell, Indian Council of Medical Research (ICMR), New Delhi, India
- Tarun Bhatnagar; ICMR School of Public Health, Indian Council of Medical Research -National Institute of Epidemiology, Chennai, Tamil Nadu, India
- Pankaj Malhotra; Department of Internal Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, India
- B Latha; Department of Transfusion Medicine, Madras Medical College, Chennai, Tamil Nadu, India
- Sunita Bundas; Department of Immunohaematology and Transfusion Medicine, SMS Medical College and Hospital, Jaipur, Rajasthan, India
- Vivek Kumar; Dept. of Critical Care Medicine, Sir H N Reliance Foundation Hospital, Mumbai, Maharashtra, India
- Ravi Dosi; Department of Respiratory Medicine, Sri Aurobindo Institute of Medical Sciences, Indore, Madhya Pradesh, India
- Janak Kumar Khambholja; Department of Internal Medicine, Smt NHL Municipal Medical College, Ahmedabad, Gujarat, India
- Rosemarie de Souza; Department of Internal Medicine, BYL Nair Charitable Hospital & TN Medical College, Mumbai, Maharashtra, India
- Raja Rao Mesipogu; Department of Internal Medicine, Gandhi Medical College, Hyderabad, Telangana, India
- Saurabh Srivastava; Department of Internal Medicine, Government Institute of Medical Sciences, Greater Noida, Uttar Pradesh, India
- Simmi Dube; Department of Internal Medicine, Gandhi Medical College, Bhopal, Madhya Pradesh, India
- Kiran Chaudhary; Department of Transfusion Medicine, Atal Bihari Vajpayee Institute of Medical Sciences and Ram Manohar Lohia Hospital, New Delhi, India
- Subash S; Department of Transfusion Medicine, Madras Medical College, Chennai, Tamil Nadu, India
- S. Anbuselvi Mattuvar K; Department of Physiology, Madras Medical College, Chennai, Tamil Nadu, India
- V Rajendran; Department of Internal Medicine, Madras Medical College, Chennai, Tamil Nadu, India
- A Sundararajaperumal; Department of Thoracic Medicine, Madras Medical College, Chennai, Tamil Nadu, India
- P Balamanikandan; Department of Internal Medicine, Madras Medical College, Chennai, Tamil Nadu, India
- R S Uma Maheswari; Department of Internal Medicine, Madras Medical College, Chennai, Tamil Nadu, India
- R Jayanthi; Department of Internal Medicine, Madras Medical College, Chennai, Tamil Nadu, India
- S Ragunanthanan; Department of Internal Medicine, Madras Medical College, Chennai, Tamil Nadu, India
- Sudhir Bhandari; Department of Internal Medicine, SMS Medical College and Hospital, Jaipur, Rajasthan, India
- Ajeet Singh; Department of Internal Medicine, SMS Medical College and Hospital, Jaipur, Rajasthan, India
- Ashok Pal; Department of Immunohaematology and Transfusion Medicine, SMS Medical College and Hospital, Jaipur, Rajasthan, India
- Anjali Handa; Department of Immunohaematology and Transfusion Medicine, SMS Medical College and Hospital, Jaipur, Rajasthan, India
- Govind Rankawat; Department of Internal Medicine, SMS Medical College and Hospital, Jaipur, Rajasthan, India
- Ketan Kargirwar; Dept. of Critical Care Medicine, Sir H N Reliance Foundation Hospital, Mumbai, Maharashtra, India
- Joyce Regi; Dept. of Transfusion Medicine, Sir H N Reliance Foundation Hospital, Mumbai, Maharashtra, India
- Darshana Rathod; Dept. of Critical Care Medicine, Sir H N Reliance Foundation Hospital, Mumbai, Maharashtra, India
- Edwin Pathrose; Dept. of Critical Care Medicine, Sir H N Reliance Foundation Hospital, Mumbai, Maharashtra, India
- Nirankar Bhutaka; Dept. of Critical Care Medicine, Sir H N Reliance Foundation Hospital, Mumbai, Maharashtra, India
- Mayur H Patel; Dept. of Critical Care and Emergency Medicine, Sir H N Reliance Foundation Hospital, Mumbai, Maharashtra, India
- Rahul J Verma; Dept. of Academics and Research, Sir H N Reliance Foundation Hospital, Mumbai, Maharashtra, India
- Kamal Malukani; Department of Pathology, Sri Aurobindo Institute of Medical Sciences, Indore, Madhya Pradesh, India
- Shivani Patel; Department of Hematology, Sri Aurobindo Institute of Medical Sciences, Indore, Madhya Pradesh, India
- Apurv Thakur; Department of Community Medicine, Sri Aurobindo Institute of Medical Sciences, Indore, Madhya Pradesh, India
- Satish Joshi; Department of Pathology, Sri Aurobindo Institute of Medical Sciences, Indore, Madhya Pradesh, India
- Rashmi Kulkarni; Department of Forensic Medicine, Sri Aurobindo Institute of Medical Sciences, Indore, Madhya Pradesh, India
- Nilay N Suthar; Department of Internal Medicine, Smt NHL Municipal Medical College, Ahmedabad, Gujarat, India
- Nehal M Shah; Department of Internal Medicine, Smt NHL Municipal Medical College, Ahmedabad, Gujarat, India
- Hemang M Purohit; Department of Internal Medicine, Smt NHL Municipal Medical College, Ahmedabad, Gujarat, India
- Cherry K Shah; Department of Pathology, Smt NHL Municipal Medical College, Ahmedabad, Gujarat, India
- Monila N Patel; Department of Internal Medicine, Smt NHL Municipal Medical College, Ahmedabad, Gujarat, India
- Saket Shah; Department of Hematology, Smt NHL Municipal Medical College, Ahmedabad, Gujarat, India
- Smit H Shah; Department of Internal Medicine, Smt NHL Municipal Medical College, Ahmedabad, Gujarat, India
- Tehsim Memon; Department of Internal Medicine, Smt NHL Municipal Medical College, Ahmedabad, Gujarat, India
- Vishal R Beriwala; Department of Internal Medicine, Smt NHL Municipal Medical College, Ahmedabad, Gujarat, India
- Kusum Jashnani; Department of Pathology, BYL Nair Charitable Hospital & TN Medical College, Mumbai, Maharashtra, India
- Fatema Ezzy; Department of Internal Medicine, BYL Nair Charitable Hospital & TN Medical College, Mumbai, Maharashtra, India
- Simran Agrawal; Department of Internal Medicine, BYL Nair Charitable Hospital & TN Medical College, Mumbai, Maharashtra, India
- Rakesh Bhadade; Department of Internal Medicine, BYL Nair Charitable Hospital & TN Medical College, Mumbai, Maharashtra, India
- Atish M N; Department of Internal Medicine, BYL Nair Charitable Hospital & TN Medical College, Mumbai, Maharashtra, India
- Tushar Madke; Department of Internal Medicine, BYL Nair Charitable Hospital & TN Medical College, Mumbai, Maharashtra, India
- Vikash Kavishwar; Department of Internal Medicine, BYL Nair Charitable Hospital & TN Medical College, Mumbai, Maharashtra, India
- Ramesh Waghmare; Department of Pathology, BYL Nair Charitable Hospital & TN Medical College, Mumbai, Maharashtra, India
- Nitin Valvi; Department of Pathology, BYL Nair Charitable Hospital & TN Medical College, Mumbai, Maharashtra, India
- B Thrilok Chander; Department of Internal Medicine, Gandhi Medical College, Secunderabad, Telangana, India
- A Vinaya Sekhar; Department of Internal Medicine, Gandhi Medical College, Secunderabad, Telangana, India
- Akhilesh Kumar Maurya; Department of Internal Medicine, Gandhi Medical College, Secunderabad, Telangana, India
- K Hemanth; Department of Internal Medicine, Gandhi Medical College, Secunderabad, Telangana, India
- K Nagamani; Department of Microbiology, Gandhi Medical College, Secunderabad, Telangana, India
- K Sudha; Department of Blood Bank, Gandhi Medical College, Secunderabad, Telangana, India
- T Ravi Chandra; Department of Internal Medicine, Gandhi Medical College, Secunderabad, Telangana, India
- K Tushara Rao; Department of Internal Medicine, Gandhi Medical College, Secunderabad, Telangana, India
- J Vyshnavi; Department of Internal Medicine, Gandhi Medical College, Secunderabad, Telangana, India
- Rashmi Upadhyay; Department of Pulmonary Medicine, Government Institute of Medical Sciences, Greater Noida, Uttar Pradesh, India
- Shalini Bahadur; Department of Pathalogy, Government Institute of Medical Sciences, Greater Noida, Uttar Pradesh, India
- Rambha Pathak; Department of Community Medicine, Government Institute of Medical Sciences, Greater Noida, Uttar Pradesh, India
- Shikha Seth; Department of Obstetrics and Gynecology, Government Institute of Medical Sciences, Greater Noida, Uttar Pradesh, India
- Rakesh Gupta; Department of Pediatrics, Government Institute of Medical Sciences, Greater Noida, Uttar Pradesh, India
- Rita Saxena; Department of Internal Medicine, Gandhi Medical College, Bhopal, Madhya Pradesh, India
- Preksha Dwivedi; Department of Internal Medicine, Gandhi Medical College, Bhopal, Madhya Pradesh, India
- Reeni Malik; Department of Pathology Gandhi Medical College, Bhopal, Madhya Pradesh, India
- Deepti Chourasia; Department of Microbiology, Gandhi Medical College, Bhopal, Madhya Pradesh, India
- Jaya Lalwani; Department of Microbiology, Gandhi Medical College, Bhopal, Madhya Pradesh, India
- UM Sharma; Department of Pathology, Gandhi Medical College, Bhopal, Madhya Pradesh, India
- JL Marko; Department of Pharmacology, Gandhi Medical College, Bhopal, Madhya Pradesh, India
- Amit Suri; Department of Pulmonary Medicine, Atal Bihari Vajpayee Institute of Medical Sciences and Ram Manohar Lohia Hospital, New Delhi, India
- Vijay Kumar; Department of Pathology, Atal Bihari Vajpayee Institute of Medical Sciences and Ram Manohar Lohia Hospital, New Delhi, India
- Rajnish Kaushik; Department of Pulmonary Medicine, Atal Bihari Vajpayee Institute of Medical Sciences and Ram Manohar Lohia Hospital, New Delhi, India
- Parul Kodan; Department of Internal Medicine, Atal Bihari Vajpayee Institute of Medical Sciences and Ram Manohar Lohia Hospital, New Delhi, India
- Bhabani Prasad Acharya; Department of Community Medicine, Atal Bihari Vajpayee Institute of Medical Sciences and Ram Manohar Lohia Hospital, New Delhi, India
- Kuldeep Kumar Gaur; Department of Internal Medicine, Atal Bihari Vajpayee Institute of Medical Sciences and Ram Manohar Lohia Hospital, New Delhi, India
- Anubhav Gupta; Department of Transfusion Medicine, Atal Bihari Vajpayee Institute of Medical Sciences and Ram Manohar Lohia Hospital, New Delhi, India
- Prerna Sachdeva; Department of Transfusion Medicine, Atal Bihari Vajpayee Institute of Medical Sciences and Ram Manohar Lohia Hospital, New Delhi, India
- Shruti Dogra; Department of Pathology, Atal Bihari Vajpayee Institute of Medical Sciences and Ram Manohar Lohia Hospital, New Delhi, India
- Aikaj Jindal; Department of Transfusion Medicine, Satguru Partap Singh Hospitals, Ludhiana, Punjab, India
- M Joseph John; Department of Clinical Hematology, Christian Medical College, Ludhiana, Punjab, India
- Avtar Singh Dhanju; Department of Internal Medicine, Government Medical College, Amritsar, Punjab, India
- Ranjana Khetrepal; Department of Anesthesia, Government Medical College, Amritsar, Punjab, India
- Neeraj Sharma; Department of Transfusion, Government Medical College, Amritsar, Punjab, India
- Neetu Kukar; Department of Immunohematology and Blood Transfusion, Guru Gobind Singh Medical College and Hospital, Faridkot, Punjab, India
- Divya Kavita; Department of Anaesthesia, Guru Gobind Singh Medical College and Hospital, Faridkot, Punjab, India
- Rajesh Kumar; Department of Immunohematology and Blood Transfusion, Dayanand Medical College and Hospital, Ludhiana, Punjab, India
- Rajesh Mahajan; Department of Internal Medicine, Dayanand Medical College and Hospital, Ludhiana, Punjab, India
- Gurpreet Singh; Department of Respiratory Medicine, Satguru Partap Singh Hospitals, Ludhiana, Punjab, India
- Jaspreet Kaur; Department of Microbiology, Satguru Partap Singh Hospitals, Ludhiana, Punjab, India
- Raminder Pal Singh; Department of Internal Medicine, Government Medical College, Patiala, Punjab, India
- Rajni Bassi; Department of Transfusion Medicine, Government Medical College, Patiala, Punjab, India
- Swapneil Parikh; Department of Infectious Diseases, Kasturba Hospital, Mumbai, Maharashtra, India
- Om Shrivastav; Department of Infectious Diseases, Kasturba Hospital, Mumbai, Maharashtra, India
- Jayanthi Shastri; Department of Microbiology, Kasturba Hospital, Mumbai, Maharashtra, India
- Maherra Desai; Clinical Research Department, Kasturba Hospital, Mumbai, Maharashtra, India
- Shreevatsa Udupa; Clinical Research Department, Kasturba Hospital, Mumbai, Maharashtra, India
- Varun A Bafna; Department of Medicine, RCSM Government Medical College, Kolhapur, Maharashtra, India
- Vijay Barge; Department of Medicine, RCSM Government Medical College, Kolhapur, Maharashtra, India
- Rajendra Madane; Department of Blood Bank, RCSM Government Medical College, Kolhapur, Maharashtra, India
- Sheetal Yadav; Department of Medicine, RCSM Government Medical College, Kolhapur, Maharashtra, India
- Sanjeev Mishra; All India Institute of Medical Sciences, Jodhpur, Rajasthan, India
- Archana Bajpayee; Department of Transfusion Medicine, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India
- M K Garg; Department of Internal Medicine, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India
- G K Bohra; Department of Internal Medicine, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India
- Vijaylakshmi Nag; Department of Microbiology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India
- Puneeth Babu Anne; Department of Transfusion Medicine, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India
- Mohd Nadeem; Department of Internal Medicine, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India
- Pallavi Singh; Department of Transfusion Medicine, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India
- Ram Niwas; Department of Pulmonary Medicine, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India
- Niranjan Shiwaji Khaire; Department of Internal Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, India
- Rattiram Sharma; Department of Transfusion Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, India
- Mini p Singh; Department of Virology, Post Graduate Institute of Medical Education and Research, Chandigarh, India
- Naresh Sachdeva; Department of Endocrinology, Post Graduate Institute of Medical Education and Research, Chandigarh, India
- Suchet Sachdev; Department of Transfusion Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, India
- Rekha Hans; Department of Transfusion Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, India
- Vikas Suri; Department of Internal Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, India
- L N Yaddanapudi; Department of Anesthesiology and Intensive Care, Post Graduate Institute of Medical Education and Research, Chandigarh, India
- PVM Lakshmi; School of Public Health, Post Graduate Institute of Medical Education and Research, Chandigarh, India
- Neha Singh; Department of Transfusion Medicine, All India Institute of Medical Sciences, Patna, Bihar, India
- Divendu Bhushan; Department of Internal Medicine, All India Institute of Medical Sciences, Patna, Bihar, India
- Neeraj Kumar; Department of Trauma and Emergency Medicine, All India Institute of Medical Sciences, Patna, Bihar, India
- Muralidhar Tambe; Department of Community Medicine Byramjee Jeejeebhoy Medical College, Pune, Maharashtra, India
- Sonali Salvi; Department of Internal Medicine, Byramjee Jeejeebhoy Medical College, Pune, Maharashtra, India
- Nalini Kadgi; Department of Pathology, Byramjee Jeejeebhoy Medical College, Pune, Maharashtra, India
- Shashikala Sangle; Department of Internal Medicine, Byramjee Jeejeebhoy Medical College, Pune, Maharashtra, India
- Leena Nakate; Department of Pathology, Byramjee Jeejeebhoy Medical College, Pune, Maharashtra, India
- Samir Joshi; Department of E.N.T., Byramjee Jeejeebhoy Medical College, Pune, Maharashtra, India
- Rajesh Karyakarte; Department of Microbiology, Byramjee Jeejeebhoy Medical College, Pune, Maharashtra, India
- Suraj Goyanka; Department of Internal Medicine, Byramjee Jeejeebhoy Medical College, Pune, Maharashtra, India
- Nimisha Sharma; Department of Immunohematology and blood transfusion, ESIC Medical College and Hospital, Faridabad, Haryana, India
- Nikhil Verma; Department of Internal Medicine, ESIC Medical College and Hospital, Faridabad, Haryana, India
- Asim Das; ESIC Medical College and Hospital, Faridabad, Haryana, India
- Monika Bahl; Clinical Development Services Agency, Translational Health Sciences and Technology Institute, Faridabad, Haryana, India
- Nitya Wadhwa; Clinical Development Services Agency, Translational Health Sciences and Technology Institute, Faridabad, Haryana, India
- Shreepad Bhat; Department of Internal Medicine, Smt. Kashi Bai Navale Medical College, Pune, Maharashtra, India
- Shweta Deshmukh; Department of Internal Medicine, Smt. Kashi Bai Navale Medical College, Pune, Maharashtra, India
- Vrushali Wagh; Department of Internal Medicine, Smt. Kashi Bai Navale Medical College, Pune, Maharashtra, India
- Atul Kulkarni; Department of Blood Bank, Jankalyan Blood bank, Pune, Maharashtra, India
- Tanvi Yardi; Department of Blood Bank, Jankalyan Blood bank, Pune, Maharashtra, India
- Ram S Kalgud; Department of Internal Medicine, Karnataka Institute of Medical Sciences, Hubballi, Karnataka, India
- Purushottam Reddy; Department of Pathology, Karnataka Institute of Medical Sciences, Hubballi, Karnataka, India
- Kavitha Yevoor; Department of Pathology, Karnataka Institute of Medical Sciences, Hubballi, Karnataka, India
- Prashanth Gajula; Department of Internal Medicine, Karnataka Institute of Medical Sciences, Hubballi, Karnataka, India
- Vivek Maleyur; Department of Internal Medicine, Karnataka Institute of Medical Sciences, Hubballi, Karnataka, India
- Medini S; Department of Internal Medicine, Karnataka Institute of Medical Sciences, Hubballi, Karnataka, India
- Mohith HN; Department of Internal Medicine, Karnataka Institute of Medical Sciences, Hubballi, Karnataka, India
- Anil Gurtoo; Department of Internal Medicine, Lady Hardinge Medical College, New Delhi, India
- Ritika Sud; Department of Internal Medicine, Lady Hardinge Medical College, New Delhi, India
- Sangeeta Pahuja; Department of Transfusion Medicine, Lady Hardinge Medical College, New Delhi, India
- Anupam Prakash; Department of Internal Medicine, Lady Hardinge Medical College, New Delhi, India
- Parijat Gogoi; Department of Biochemistry, Lady Hardinge Medical College, New Delhi, India
- Shailja Shukla; Department of Pathology, Lady Hardinge Medical College, New Delhi, India
- D Himanshu Reddy; Department of Internal Medicine, King George's Medical University, Lucknow, Uttar Pradesh, India
- Tulika Chandra; Department of Transfusion Medicine, King George's Medical University, Lucknow, Uttar Pradesh, India
- Saurabh Pandey; Department of Internal Medicine, King George's Medical University, Lucknow, Uttar Pradesh, India
- Pradeep Maurya; Department of Internal Medicine, King George's Medical University, Lucknow, Uttar Pradesh, India
- Ali Wahid; Department of Pathology and Biochemistry, King George's Medical University, Lucknow, Uttar Pradesh, India
- Vivek Kumar; Department of Internal Medicine, King George's Medical University, Lucknow, Uttar Pradesh, India
- Kamlesh Upadhyay; Department of Internal Medicine, Byramjee Jeejeebhoy Medical College, Ahmedabad, Gujarat, India
- Nidhi Bhatnagar; Department of Transfusion Medicine, Byramjee Jeejeebhoy Medical College, Ahmedabad, Gujarat, India
- Nilima Shah; Department of Internal Medicine, Byramjee Jeejeebhoy Medical College, Ahmedabad, Gujarat, India
- Mamta Shah; Department of Transfusion Medicine, Byramjee Jeejeebhoy Medical College, Ahmedabad, Gujarat, India
- Tarak Patel; Department of Transfusion Medicine, Byramjee Jeejeebhoy Medical College, Ahmedabad, Gujarat, India
- Ram Mohan Jaiswal; Blood Center & Transplant Immunology Lab, Mahatma Gandhi University of Medical Sciences and Technology, Jaipur, Rajasthan, India
- Ashish Jain; Department of Respiratory Medicine, Mahatma Gandhi University of Medical Sciences and Technology, Jaipur, Rajasthan, India
- Shweta Sharma; Department of Pathology, Mahatma Gandhi University of Medical Sciences and Technology, Jaipur, Rajasthan, India
- Puneet Rijhwani; Department of Internal Medicine, Mahatma Gandhi University of Medical Sciences and Technology, Jaipur, Rajasthan, India
- Naveen Gupta; Department of Clinical Hematology, Mahatma Gandhi University of Medical Sciences and Technology, Jaipur, Rajasthan, India
- Tinkal C Patel; Department of Internal Medicine, Government Medical College, Surat, Gujarat, India
- Mahesh G Solu; Department of Internal Medicine, Government Medical College, Surat, Gujarat, India
- Jitendra Patel; Department of Immunology & Blood Transfusion, Government Medical College, Surat, Gujarat, India
- Yash R Shah; Department of Internal Medicine, Government Medical College, Surat, Gujarat, India
- Mayur Jarag; Department of Immunology and Blood Transfusion, Government Medical College, Surat, Gujarat, India
- Varsha Godbole; Department of Internal Medicine, GMERS Medical College and Hospital, Gotri, Vadodara, Gujarat, India
- Meenakshi Shah; Department of Internal Medicine, GMERS Medical College and Hospital, Gotri, Vadodara, Gujarat, India
- Rikin Raj; Department of Internal Medicine, GMERS Medical College and Hospital, Gotri, Vadodara, Gujarat, India
- Irfan Nagori; Department of Internal Medicine, GMERS Medical College and Hospital, Gotri, Vadodara, Gujarat, India
- Pramod R Jha; Department of Internal Medicine, Sumandeep Vidyapeeth and Dhiraj Hospital, Vadodara, Gujarat, India
- Arti D Shah; Department of Respiratory Medicine, Sumandeep Vidyapeeth and Dhiraj Hospital, Vadodara, Gujarat, India
- Gowtham Yeeli; Department of Internal Medicine, Sumandeep Vidyapeeth and Dhiraj Hospital, Vadodara, Gujarat, India
- Archit Jain; Department of Internal Medicine, Sumandeep Vidyapeeth and Dhiraj Hospital, Vadodara, Gujarat, India
- Rooppreet Kaur Gill; Department of Internal Medicine, Sumandeep Vidyapeeth and Dhiraj Hospital, Vadodara, Gujarat, India
- KV Sreedhar Babu; Department of Transfusion Medicine, Sri Venkateswra Institute of Medical Sciences, Tirupati, Andhra Pradesh, India
- B Suresh Babu; Department of Transfusion Medicine, Sri Venkateswra Institute of Medical Sciences, Tirupati, Andhra Pradesh, India
- Alladi Mohan; Department of Internal Medicine, Sri Venkateswra Institute of Medical Sciences, Tirupati, Andhra Pradesh, India
- B Vengamma; Department of Neurology, Sri Venkateswra Institute of Medical Sciences,Tirupati, Andhra Pradesh, India
- K Chandra Sekhar; Department of Internal Medicine, Sri Venkateswra Institute of Medical Sciences,Tirupati, Andhra Pradesh, India
- Srinivasulu Damam; Department of Internal Medicine, Kurnool Medical College, Kurnool, Andhra Pradesh, India
- K Narsimhulu; Department of Internal Medicine, Kurnool Medical College, Kurnool, Andhra Pradesh, India
- C Aparna; Department of Pathology, Kurnool Medical College, Kurnool, Andhra Pradesh, India
- G Baleswari; Professor, Department of Pathology, Kurnool Medical College, Kurnool, Andhra Pradesh, India
- Ravindranath Reddy K; Professor, Department of Internal Medicine, Kurnool Medical College, Kurnool, Andhra Pradesh, India
- P Chandrasekhar; Department of Cardiology, Kurnool Medical College, Kurnool, Andhra Pradesh, India
- Sunil Jodharam Panjwani; Department of Internal Medicine, Government Medical College, Bhavnagar, Gujarat, India
- Pankaj J Akholkar; Department of Internal Medicine, Government Medical College, Bhavnagar, Gujarat, India
- Kairavi Parthesh Joshi; Department of Microbiology, Government Medical College, Bhavnagar, Gujarat, India
- Pragnesh H Shah; Department of Microbiology, Government Medical College, Bhavnagar, Gujarat, India
- Manish Barvaliya; Department of Internal Medicine, Government Medical College, Bhavnagar, Gujarat, India
- Milind Baldi; Department of Respiratory Medicine, Mahatma Gandhi Memorial Medical College, Indore, Madhya Pradesh, India
- Ashok Yadav; Department of Transfusion Medicine, Mahatma Gandhi Memorial Medical College, Indore, Madhya Pradesh, India
- Manoj Gupta; Department of Internal Medicine, Mahatma Gandhi Memorial Medical College, Indore, Madhya Pradesh, India
- Nitin Rawat; Department of Internal Medicine, Mahatma Gandhi Memorial Medical College, Indore, Madhya Pradesh, India
- Dilip Chawda; Department of Respiratory Medicine, Mahatma Gandhi Memorial Medical College, Indore, Madhya Pradesh, India
- M Natarajan; Department of Internal Medicine, Madurai Medical College, Madurai, Tamil Nadu, India
- M Sintha; Department of Immunohematology and Blood Transfusion, Madurai Medical College, Madurai, Tamil Nadu, India
- David Pradeep Kumar; Department of Internal Medicine, Madurai Medical College, Madurai, Tamil Nadu, India
- Fathhur Rabbani; Department of Internal Medicine, Madurai Medical College, Madurai, Tamil Nadu, India
- Vrushali Khirid Khadke; Department of Interventional Pulmonology, Poona Hospital and Research Center, Pune, Maharashtra, India
- Dattatray Patki; Department of Internal Medicine, Poona Hospital and Research Center, Pune, Maharashtra, India
- Sonali Marathe; Department of Pathology & Transfusion Medicine, Poona Hospital and Research Center, Pune, Maharashtra, India
- Clyde D Souza; Department of Internal Medicine, Poona Hospital and Research Center, Pune, Maharashtra, India
- Vipul Tadha; Department of General Medicine, Poona Hospital and Research Center, Pune, Maharashtra, India
- Satyam Arora; Department of Transfusion Medicine, Super Specialty Paediatric Hospital and Post Graduate Teaching Institute, Noida, Uttar Pradesh, India
- Devendra Kumar Gupta; Department of Paediatric Surgery, Super Specialty Paediatric Hospital and Post Graduate Teaching Institute, Noida, Uttar Pradesh, India
- Seema Dua; Department of Transfusion Medicine, Super Specialty Paediatric Hospital and Post Graduate Teaching Institute, Noida, Uttar Pradesh, India
- Nitu Chauhan; Department of Transfusion Medicine, Sarojini Naidu Medical College, Agra, Uttar Pradesh, India
- Ajeet Singh Chahar; Department of Internal Medicine, Sarojini Naidu Medical College, Agra, Uttar Pradesh, India
- Joy John Mammen; Department of Transfusion Medicine, Christian Medical College, Vellore, Tamil Nadu, India
- Snehil Kumar; Department of Transfusion Medicine, Christian Medical College, Vellore, Tamil Nadu, India
- Dolly Daniel; Department of Transfusion Medicine, Christian Medical College, Vellore, Tamil Nadu, India
- Ravindraa Singh; Department of Transfusion Medicine, Aditya Birla Memorial Hospital, Pune, Maharashtra, India
- Venkatesh Dhat; Department of Critical Care Medicine, Aditya Birla Memorial Hospital, Pune, Maharashtra, India
- Yogesh Agarwal; Department of Pulmonary Medicine, Aditya Birla Memorial Hospital, Pune, Maharashtra, India
- Sohini Arora; Department of Laboratory Medicine, Aditya Birla Memorial Hospital, Pune, Maharashtra, India
- Ashish Pathak; Department of Paediatrics, RD Gardi Medical College, Ujjain, Madhya Pradesh, India
- Manju Purohit; Department of Pathology, RD Gardi Medical College, Ujjain, Madhya Pradesh, India
- Ashish Sharma; Department of Medicine, RD Gardi Medical College, Ujjain, Madhya Pradesh, India
- Jayashree Sharma; Department Transfusion Medicine, Seth GS Medical College and KEM Hospital, Mumbai, Maharashtra, India
- Manisha Madkaikar; Indian Council of Medical Research - National Institute of Immunohaematology, Mumbai, Maharashtra, India
- Kavita Joshi; Department Internal Medicine, Seth GS Medical College and KEM Hospital, Mumbai, Maharashtra, India
- Reetika Malik Yadav; Indian Council of Medical Research - National Institute of Immunohaematology, Mumbai, Maharashtra, India
- Swarupa Bhagwat; Department of Transfusion Medicine, Seth GS Medical College and KEM Hospital, Mumbai, Maharashtra, India
- Niteen D Karnik; Department of Internal Medicine, Lokmanya Tilak Municipal Medical College & General Hospital, Mumbai, Maharashtra, India
- Yojana A Gokhale; Department of Internal Medicine, Lokmanya Tilak Municipal Medical College & General Hospital, Mumbai, Maharashtra, India
- Leena Naik; Department of Pathology, Lokmanya Tilak Municipal Medical College & General Hospital, Mumbai, Maharashtra, India
- Sangita Margam; Department of Pathology, Lokmanya Tilak Municipal Medical College & General Hospital, Mumbai, Maharashtra, India
- Santasabuj Das; Division of Clinical Medicine, National Institute of Cholera and Enteric Diseases, Indian Council of Medical Research, Kolkata, West Bengal, India
- Alka Turuk; Division of Epidemiology and Communicable Division, Indian Council of Medical Research, New Delhi, India
- V Saravana Kumar; Epidemiology and Biostatistics Division, Indian Council of Medical Research - National Institute of Epidemiology, Chennai, Tamil, India
- K Kanagasabai; Computing and Informatics Science Division, Indian Council of Medical Research - National Institute of Epidemiology, Chennai, Tamil, India
- R Sabarinathan; Project Division, Indian Council of Medical Research, National Institute of Epidemiology, Chennai, Tamil, India
- Gururaj Deshpande; Diagnostic Virology Group, Indian Council of Medical Research, National Institute Virology, Pune, Maharashtra, India
- Sharda Sharma; Diagnostic Virology Group, Indian Council of Medical Research, National Institute Virology, Pune, Maharashtra, India
- Rashmi Gunjikar; Senior Technical Officer, Diagnostic Virology Group, Indian Council of Medical Research, National Institute Virology, Pune, Maharashtra, India
- Anita Shete; Maximum Containment Laboratory, Indian Council of Medical Research, National Institute Virology, Pune, Maharashtra, India
- Darpan Phagiwala; Diagnostic Virology Group, Indian Council of Medical Research, National Institute Virology, Pune, Maharashtra, India
- Chetan Patil; Diagnostic Virology Group, Indian Council of Medical Research, National Institute Virology, Pune, Maharashtra, India
- Snehal Shingade; Diagnostic Virology Group, Indian Council of Medical Research, National Institute Virology, Pune, Maharashtra, India
- Kajal Jarande; Diagnostic Virology Group, Indian Council of Medical Research, National Institute Virology, Pune, Maharashtra, India
- Himanshu Kaushal; Human Influenza Group, Indian Council of Medical Research, National Institute Virology, Pune, Maharashtra, India
- Pragya Yadav; Maximum Containment Laboratory, Indian Council of Medical Research, National Institute Virology, Pune, Maharashtra, India
- Gajanan Sapkal; Diagnostic Virology Group, Indian Council of Medical Research, National Institute Virology, Pune, Maharashtra, India
- Priya Abraham; Director, Indian Council of Medical Research, National Institute Virology, Pune, Maharashtra, India
Preprint
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| ID: ppmedrxiv-20187252
ABSTRACT
ObjectivesConvalescent plasma (CP) as a passive source of neutralizing antibodies and immunomodulators is a century-old therapeutic option used for the management of viral diseases. We investigated its effectiveness for the treatment of COVID-19. DesignOpen-label, parallel-arm, phase II, multicentre, randomized controlled trial. SettingThirty-nine public and private hospitals across India. ParticipantsHospitalized, moderately ill confirmed COVID-19 patients (PaO2/FiO2 200-300 or respiratory rate > 24/min and SpO2 [≤] 93% on room air). InterventionParticipants were randomized to either control (best standard of care (BSC)) or intervention (CP + BSC) arm. Two doses of 200 mL CP was transfused 24 hours apart in the intervention arm. Main Outcome MeasureComposite of progression to severe disease (PaO2/FiO2< 100) or all-cause mortality at 28 days post-enrolment. ResultsBetween 22nd April to 14th July 2020, 464 participants were enrolled; 235 and 229 in intervention and control arm, respectively. Composite primary outcome was achieved in 44 (18.7%) participants in the intervention arm and 41 (17.9%) in the control arm [aOR 1.09; 95% CI 0.67, 1.77]. Mortality was documented in 34 (13.6%) and 31 (14.6%) participants in intervention and control arm, respectively [aOR) 1.06 95% CI -0.61 to 1.83]. InterpretationCP was not associated with reduction in mortality or progression to severe COVID-19. This trial has high generalizability and approximates real-life setting of CP therapy in settings with limited laboratory capacity. A priori measurement of neutralizing antibody titres in donors and participants may further clarify the role of CP in management of COVID-19. Trial registrationThe trial was registered with Clinical Trial Registry of India (CTRI); CTRI/2020/04/024775.
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Full text:
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Collection:
09-preprints
Database:
PREPRINT-MEDRXIV
Type of study:
Experimental_studies
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Prognostic_studies
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Rct
Language:
En
Year:
2020
Document type:
Preprint