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Early introductions and community transmission of SARS-CoV-2 variant B.1.1.7 in the United States
Tara Alpert; Anderson F. Brito; Erica Lasek-Nesselquist; Jessica Rothman; Andrew L. Valesano; Matthew J. MacKay; Mary E. Petrone; Mallery I. Breban; Anne E. Watkins; Chantal B.F. Vogels; Chaney C. Kalinich; Simon Dellicour; Alexis Russell; John P. Kelly; Matthew Shudt; Jonathan Plitnick; Erasmus Schneider; William J. Fitzsimmons; Gaurav Khullar; Jessica Metti; Joel T. Dudley; Megan Nash; Nike Beaubier; Jianhui Wang; Chen Liu; Pei Hui; Anthony Muyombwe; Randy Downing; Jafar Razeq; Stephen M. Bart; Ardath Grills; Stephanie M. Morrison; Steven Murphy; Caleb Neal; Eva Laszlo; Hanna Rennert; Melissa Cushing; Lars Westblade; Priya Velu; Arryn Craney; Kathy A. Fauntleroy; David R. Peaper; Marie L. Landry; Peter W. Cook; Joseph R. Fauver; Christopher E. Mason; Adam S. Lauring; Kirsten St. George; Duncan R. MacCannell; Nathan D. Grubaugh.
Affiliation
  • Tara Alpert; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT 06510, USA
  • Anderson F. Brito; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT 06510, USA
  • Erica Lasek-Nesselquist; Wadsworth Center, New York State Department of Health, Albany, NY 12208, USA
  • Jessica Rothman; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT 06510, USA
  • Andrew L. Valesano; Department of Internal Medicine, Department of Microbiology and Immunology, University of Michigan, Ann Arbor, MI 48109, USA
  • Matthew J. MacKay; Tempus Labs, Chicago, IL 60654, USA
  • Mary E. Petrone; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT 06510, USA
  • Mallery I. Breban; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT 06510, USA
  • Anne E. Watkins; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT 06510, USA
  • Chantal B.F. Vogels; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT 06510, USA
  • Chaney C. Kalinich; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT 06510, USA
  • Simon Dellicour; Spatial Epidemiology Lab (SpELL), Universite Libre de Bruxelles, Bruxelles, Belgium and Laboratory of Clinical and Epidemiological Virology, Department of Micro
  • Alexis Russell; Wadsworth Center, New York State Department of Health, Albany, NY 12208, USA
  • John P. Kelly; Wadsworth Center, New York State Department of Health, Albany, NY 12208, USA
  • Matthew Shudt; Wadsworth Center, New York State Department of Health, Albany, NY 12208, USA and Department of Biomedical Sciences, University at Albany, SUNY, Albany, NY 12222
  • Jonathan Plitnick; Wadsworth Center, New York State Department of Health, Albany, NY 12208, USA and Department of Biomedical Sciences, University at Albany, SUNY, Albany, NY 12222
  • Erasmus Schneider; Wadsworth Center, New York State Department of Health, Albany, NY 12208, USA and Department of Biomedical Sciences, University at Albany, SUNY, Albany, NY 12222
  • William J. Fitzsimmons; Department of Internal Medicine, Department of Microbiology and Immunology, University of Michigan, Ann Arbor, MI 48109, USA
  • Gaurav Khullar; Tempus Labs, Chicago, IL 60654, USA
  • Jessica Metti; Tempus Labs, Chicago, IL 60654, USA
  • Joel T. Dudley; Tempus Labs, Chicago, IL 60654, USA
  • Megan Nash; Tempus Labs, Chicago, IL 60654, USA
  • Nike Beaubier; Tempus Labs, Chicago, IL 60654, USA
  • Jianhui Wang; Department of Pathology, Yale University School of Medicine, New Haven, CT 06510, USA
  • Chen Liu; Department of Pathology, Yale University School of Medicine, New Haven, CT 06510, USA
  • Pei Hui; Department of Pathology, Yale University School of Medicine, New Haven, CT 06510, USA
  • Anthony Muyombwe; Connecticut State Department of Public Health, Rocky Hill, CT 06067, USA
  • Randy Downing; Connecticut State Department of Public Health, Rocky Hill, CT 06067, USA
  • Jafar Razeq; Connecticut State Department of Public Health, Rocky Hill, CT 06067, USA
  • Stephen M. Bart; Connecticut State Department of Public Health, Rocky Hill, CT 06067, USA and Centers for Disease Control and Prevention, Atlanta, GA 30329, USA
  • Ardath Grills; Centers for Disease Control and Prevention, Atlanta, GA 30329, USA
  • Stephanie M. Morrison; Centers for Disease Control and Prevention, Atlanta, GA 30329, USA
  • Steven Murphy; Murphy Medical Associates, Greenwich, CT 06830, USA
  • Caleb Neal; Murphy Medical Associates, Greenwich, CT 06830, USA
  • Eva Laszlo; Murphy Medical Associates, Greenwich, CT 06830, USA
  • Hanna Rennert; Department of Pathology and Laboratory Medicine, New York Presbyterian Hospital-Weill Cornell Medicine, New York, NY 10021, USA
  • Melissa Cushing; Department of Pathology and Laboratory Medicine, New York Presbyterian Hospital-Weill Cornell Medicine, New York, NY 10021, USA
  • Lars Westblade; Department of Pathology and Laboratory Medicine, New York Presbyterian Hospital-Weill Cornell Medicine, New York, NY 10021, USA
  • Priya Velu; Department of Pathology and Laboratory Medicine, New York Presbyterian Hospital-Weill Cornell Medicine, New York, NY 10021, USA
  • Arryn Craney; Department of Pathology and Laboratory Medicine, New York Presbyterian Hospital-Weill Cornell Medicine, New York, NY 10021, USA
  • Kathy A. Fauntleroy; Department of Pathology and Laboratory Medicine, New York Presbyterian Hospital-Weill Cornell Medicine, New York, NY 10021, USA
  • David R. Peaper; Departments of Laboratory Medicine and Medicine, Yale School of Medicine, New Haven, CT 06510, USA
  • Marie L. Landry; Departments of Laboratory Medicine and Medicine, Yale School of Medicine, New Haven, CT 06510, USA
  • Peter W. Cook; Centers for Disease Control and Prevention, Atlanta, GA 30329, USA
  • Joseph R. Fauver; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT 06510, USA
  • Christopher E. Mason; Tempus Labs, Chicago, IL 60654, USA and Department of Pathology and Laboratory Medicine, New York Presbyterian Hospital-Weill Cornell Medicine, New York, NY 100
  • Adam S. Lauring; Department of Internal Medicine, Department of Microbiology and Immunology, University of Michigan, Ann Arbor, MI 48109, USA
  • Kirsten St. George; Wadsworth Center, New York State Department of Health, Albany, NY 12208, USA and Department of Biomedical Sciences, University at Albany, SUNY, Albany, NY 12222
  • Duncan R. MacCannell; Centers for Disease Control and Prevention, Atlanta, GA 30329, USA
  • Nathan D. Grubaugh; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT 06510, USA and Department of Ecology and Evolutionary Biology, Yal
Preprint in En | PREPRINT-MEDRXIV | ID: ppmedrxiv-21251540
ABSTRACT
The emergence and spread of SARS-CoV-2 lineage B.1.1.7, first detected in the United Kingdom, has become a global public health concern because of its increased transmissibility. Over 2500 COVID-19 cases associated with this variant have been detected in the US since December 2020, but the extent of establishment is relatively unknown. Using travel, genomic, and diagnostic data, we highlight the primary ports of entry for B.1.1.7 in the US and locations of possible underreporting of B.1.1.7 cases. Furthermore, we found evidence for many independent B.1.1.7 establishments starting in early December 2020, followed by interstate spread by the end of the month. Finally, we project that B.1.1.7 will be the dominant lineage in many states by mid to late March. Thus, genomic surveillance for B.1.1.7 and other variants urgently needs to be enhanced to better inform the public health response.
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Full text: 1 Collection: 09-preprints Database: PREPRINT-MEDRXIV Language: En Year: 2021 Document type: Preprint
Fulltext
Add to My VHL
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Full text: 1 Collection: 09-preprints Database: PREPRINT-MEDRXIV Language: En Year: 2021 Document type: Preprint